KRT18: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

KRT18

Aliases

CK-18, CYK18, K18

Entrez Gene ID

3875

Gene Name

Keratin 18

Chromosomal Location

12q13.13

HGNC ID

HGNC:6430

Summary

KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_008351.1

RefSeq mRNA

NM_000224.3, NM_199187.1

e!Ensembl

Gene	ENSG00000111057
Transcript	ENST00000550600, ENST00000388835, ENST00000388837
Protein	ENSP00000447278, ENSP00000373487, ENSP00000373489

Gene Ontology (GO)

Show/Hide all(15 )

GO ID	Ontology	Function	Evidence	Reference
GO:0009653	Biological process	Anatomical structure morphogenesis	TAS	2434380
GO:0043000	Biological process	Golgi to plasma membrane CFTR protein transport	IDA	15529338
GO:0043066	Biological process	Negative regulation of apoptotic process	IDA	11684708
GO:0045104	Biological process	Intermediate filament cytoskeleton organization	IDA	20346438
GO:0005737	Cellular component	Cytoplasm	IDA	16424149, 20346438
GO:0005815	Cellular component	Microtubule organizing center	IDA	18000879
GO:0005882	Cellular component	Intermediate filament	IDA	10852826
GO:0005913	Cellular component	Cell-cell adherens junction	HDA	25468996
GO:0034451	Cellular component	Centriolar satellite	IDA	18000879
GO:0045095	Cellular component	Keratin filament	IDA	16424149
GO:0070062	Cellular component	Extracellular exosome	HDA	19199708
GO:0003723	Molecular function	RNA binding	HDA	22658674
GO:0005515	Molecular function	Protein binding	IPI	10852826, 10954706, 11684708, 14756564, 15671067, 15731013, 15846844, 16189514, 19549727, 20035625, 21988832, 23112296, 25416956, 25910212, 26769854, 26871637, 30021884
GO:0097110	Molecular function	Scaffold protein binding	IPI	10852826
GO:0098641	Molecular function	Cadherin binding involved in cell-cell adhesion	HDA	25468996

Protein Information

Protein Name

Keratin, type I cytoskeletal 18, cell proliferation-inducing gene 46 protein, cytokeratin 18, keratin 18, type I

Function

Involved in the uptake of thrombin-antithrombin complexes by hepatic cells (By similarity). When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection.

Refseq Proteins

NP_000215.1, NP_954657.1

UniProt

P05783

Pfam

Pfam Accession	Pfam ID
PF00038	Filament