LBP: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

LBP

Aliases

BPIFD2

Entrez Gene ID

3929

Gene Name

Lipopolysaccharide binding protein

Chromosomal Location

20q11.23

HGNC ID

HGNC:6517

Summary

The protein encoded by this gene is involved in the acute-phase immunologic response to gram-negative bacterial infections. Gram-negative bacteria contain a glycolipid, lipopolysaccharide (LPS), on their outer cell wall. Together with bactericidal permeability-increasing protein (BPI), the encoded protein binds LPS and interacts with the CD14 receptor, probably playing a role in regulating LPS-dependent monocyte responses. Studies in mice suggest that the encoded protein is necessary for the rapid acute-phase response to LPS but not for the clearance of LPS from circulation. This protein is part of a family of structurally and functionally related proteins, including BPI, plasma cholesteryl ester transfer protein (CETP), and phospholipid transfer protein (PLTP). [provided by RefSeq, Apr 2012]

RefSeq DNA

NG_034239.1

RefSeq mRNA

NM_004139.5

e!Ensembl

Gene	ENSG00000129988
Transcript	ENST00000217407
Protein	ENSP00000217407

Gene Ontology (GO)

Show/Hide all(40 )

GO ID	Ontology	Function	Evidence	Reference
GO:0002281	Biological process	Macrophage activation involved in immune response	IMP	24120359
GO:0002281	Biological process	Macrophage activation involved in immune response	ISS	2402637
GO:0006953	Biological process	Acute-phase response	IEP	12932360
GO:0006953	Biological process	Acute-phase response	ISS	2477488
GO:0006968	Biological process	Cellular defense response	ISS	2402637
GO:0008228	Biological process	Opsonization	IC	12932360
GO:0008228	Biological process	Opsonization	ISS	2477488
GO:0015920	Biological process	Lipopolysaccharide transport	IDA	8985160
GO:0031663	Biological process	Lipopolysaccharide-mediated signaling pathway	IDA	8409400, 11739189
GO:0032490	Biological process	Detection of molecule of bacterial origin	IDA	11528597
GO:0032496	Biological process	Response to lipopolysaccharide	IDA	8409400, 11739189
GO:0032720	Biological process	Negative regulation of tumor necrosis factor production	IDA	11739189
GO:0032755	Biological process	Positive regulation of interleukin-6 production	IDA	8409400
GO:0032757	Biological process	Positive regulation of interleukin-8 production	IDA	8409400
GO:0032760	Biological process	Positive regulation of tumor necrosis factor production	IDA	8409400, 12594207
GO:0032760	Biological process	Positive regulation of tumor necrosis factor production	IMP	24120359
GO:0032760	Biological process	Positive regulation of tumor necrosis factor production	ISS	2402637
GO:0033036	Biological process	Macromolecule localization	IDA	15294986
GO:0034145	Biological process	Positive regulation of toll-like receptor 4 signaling pathway	IDA	11528597
GO:0043032	Biological process	Positive regulation of macrophage activation	IDA	8409400
GO:0045087	Biological process	Innate immune response	IC	12932360
GO:0045087	Biological process	Innate immune response	ISS	2477488
GO:0045919	Biological process	Positive regulation of cytolysis	IDA	15294986
GO:0050829	Biological process	Defense response to Gram-negative bacterium	IDA	11528597
GO:0050829	Biological process	Defense response to Gram-negative bacterium	ISS	2402637
GO:0050830	Biological process	Defense response to Gram-positive bacterium	IDA	12932360
GO:0071222	Biological process	Cellular response to lipopolysaccharide	IDA	12594207
GO:0071222	Biological process	Cellular response to lipopolysaccharide	IMP	24120359
GO:0071223	Biological process	Cellular response to lipoteichoic acid	IDA	12594207
GO:0005615	Cellular component	Extracellular space	IDA	2402637, 11528597, 24120359
GO:0005615	Cellular component	Extracellular space	ISS	2477488
GO:0009986	Cellular component	Cell surface	IDA	11528597
GO:0070062	Cellular component	Extracellular exosome	HDA	19056867, 23533145
GO:0001530	Molecular function	Lipopolysaccharide binding	IDA	12594207
GO:0001530	Molecular function	Lipopolysaccharide binding	IMP	24120359
GO:0001530	Molecular function	Lipopolysaccharide binding	ISS	2477488
GO:0005102	Molecular function	Signaling receptor binding	ISS	2477488
GO:0005515	Molecular function	Protein binding	IPI	15294986, 21988832
GO:0070891	Molecular function	Lipoteichoic acid binding	IDA	12594207
GO:0071723	Molecular function	Lipopeptide binding	IDA	15294986

Protein Information

Protein Name

Lipopolysaccharide-binding protein, BPI fold containing family D, member 2, LPS-binding protein

Function

Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:7517398, PubMed:24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:7517398, PubMed:24120359).

Refseq Proteins

NP_004130.2

UniProt

P18428

Pfam

Pfam Accession	Pfam ID
PF01273	LBP_BPI_CETP
PF02886	LBP_BPI_CETP_C