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Gene Symbol |
LIF |
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Aliases |
CDF, DIA, HILDA, MLPLI |
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Entrez Gene ID |
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Gene Name |
LIF interleukin 6 family cytokine |
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Chromosomal Location |
22q12.2 |
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HGNC ID |
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Summary |
The protein encoded by this gene is a pleiotropic cytokine with roles in several different systems. It is involved in the induction of hematopoietic differentiation in normal and myeloid leukemia cells, induction of neuronal cell differentiation, regulator of mesenchymal to epithelial conversion during kidney development, and may also have a role in immune tolerance at the maternal-fetal interface. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
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RefSeq DNA |
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RefSeq mRNA |
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e!Ensembl
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| Protein Information |
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Protein Name |
Leukemia inhibitory factor, D factor, cholinergic differentiation factor, differentiation inhibitory activity, differentiation-inducing factor, differentiation-stimulating factor, hepatocyte-stimulating factor III, human interleukin in DA cells, melanoma-derived LPL inhibitor |
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Function |
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LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes |
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UniProt |
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PDB |
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Pfam |
| Pfam Accession |
Pfam ID |
| PF01291 |
LIF_OSM |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000244289 |
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Q05469 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Digestive System Diseases |
| Non-alcoholic Fatty Liver Disease |
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| Endocrine System Diseases |
| PCOS |
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| Neoplasms |
| Ovarian Cancer |
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| Psychiatric/Brain disorders |
| Delirium |
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| Mental Depression |
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| Reproductive disorders |
| Female Urogenital Diseases |
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| Subfertility, Female |
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References |
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| Ledee-Bataille N, Lapree-Delage G, Taupin J L, Dubanchet S, Taieb J, Moreau J F, Chaouat G |
| Service de Gynecologie-Obstetrique et Medecine de la Reproduction, Hopital Antoine Beclere, 157 Rue de la Porte de Trivaux, 92140 Clamart, France. Ledeenathalie@aol.com |
| Hum Reprod. 2001 Oct;16(10):2073-8. doi: 10.1093/humrep/16.10.2073. |
Abstract
BACKGROUND: The possibility that a specific cytokine profile could be detected in the ovaries of patients with polycystic ovarian syndrome (PCOS) was investigated. METHOD: Enzyme-linked immunosorbent assay (ELISA) or bioassays were used to assess the concentrations of leukaemia inhibitory factor (LIF), tumour necrosis factor, interleukin 11, gamma interferon, progesterone and oestradiol in follicular fluids from preovulatory follicles collected after ovarian stimulation from 15 PCOS patients, 15 infertile control patients with regular cycles, and 8 oocyte donors. RESULTS: LIF and progesterone concentrations were significantly lower in the follicular fluid of PCOS patients (LIF median: 265 pg/ml) compared with controls (LIF median: 816 pg/ml); LIF and progesterone follicular fluid concentrations were correlated (r = 0.720, P = 0.0001). The LH/FSH ratio was negatively correlated with LIF concentrations (r = - 0.714, P = 0.0075). Although the PCOS and control patients did not differ significantly in age, ovarian reserve or IVF indication, the implantation rate was significantly lower among the women with PCOS (IR = 9 versus 21%, P = < 0.01). CONCLUSION: The specific cytokine profile of the PCOS patients is probably related to the lower implantation rate since follicular fluid LIF appears to function as an embryotrophic agent. |
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| © 2019, Biomedical Informatics Centre, NIRRH |
National Institute for Research in Reproductive Health, Jehangir Merwanji Street, Parel, Mumbai-400 012
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