LIPC: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

LIPC

Aliases

HDLCQ12, HL, HTGL, LIPH

Entrez Gene ID

3990

Gene Name

Lipase C, hepatic type

Chromosomal Location

15q21.3

HGNC ID

HGNC:6619

Summary

LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_011465.2

RefSeq mRNA

NM_000236.3

e!Ensembl

Gene	ENSG00000166035
Transcript	ENST00000356113, ENST00000414170, ENST00000299022, ENST00000433326
Protein	ENSP00000348425, ENSP00000395569, ENSP00000299022, ENSP00000395002

Gene Ontology (GO)

Show/Hide all(26 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006633	Biological process	Fatty acid biosynthetic process	IBA	21873635
GO:0006633	Biological process	Fatty acid biosynthetic process	IDA	182536
GO:0016042	Biological process	Lipid catabolic process	IBA	21873635
GO:0019433	Biological process	Triglyceride catabolic process	IBA	21873635
GO:0019433	Biological process	Triglyceride catabolic process	IDA	182536, 2839510, 8640403
GO:0034372	Biological process	Very-low-density lipoprotein particle remodeling	IBA	21873635
GO:0034372	Biological process	Very-low-density lipoprotein particle remodeling	IDA	8640403
GO:0034373	Biological process	Intermediate-density lipoprotein particle remodeling	TAS	2839510
GO:0034374	Biological process	Low-density lipoprotein particle remodeling	IMP	3244012
GO:0034375	Biological process	High-density lipoprotein particle remodeling	IBA	21873635
GO:0034375	Biological process	High-density lipoprotein particle remodeling	IMP	3244012
GO:0034382	Biological process	Chylomicron remnant clearance	TAS	9685400
GO:0034638	Biological process	Phosphatidylcholine catabolic process	TAS	2839510
GO:0042632	Biological process	Cholesterol homeostasis	IBA	21873635
GO:0042632	Biological process	Cholesterol homeostasis	IMP	1883393
GO:0043691	Biological process	Reverse cholesterol transport	IC	14531818
GO:0070328	Biological process	Triglyceride homeostasis	IBA	21873635
GO:0070328	Biological process	Triglyceride homeostasis	IMP	1883393
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IDA	2839510
GO:0004465	Molecular function	Lipoprotein lipase activity	IBA	21873635
GO:0004620	Molecular function	Phospholipase activity	IBA	21873635
GO:0004620	Molecular function	Phospholipase activity	TAS	3244012
GO:0004806	Molecular function	Triglyceride lipase activity	IDA	182536, 2839510
GO:0016298	Molecular function	Lipase activity	IBA	21873635
GO:0034185	Molecular function	Apolipoprotein binding	IBA	21873635

Protein Information

Protein Name

Hepatic triacylglycerol lipase, Triacylglycerol lipase, hepatic lipase, lipase member C, lipase, hepatic

Function

Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin

Refseq Proteins

NP_000227.2

UniProt

P11150

Pfam

Pfam Accession	Pfam ID
PF00151	Lipase
PF01477	PLAT