LPA: Polycystic Ovarian Syndrome Database

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LPA

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

LPA

Aliases

AK38, APOA, LP

Entrez Gene ID

4018

Gene Name

Lipoprotein(a)

Chromosomal Location

6q25.3-q26

HGNC ID

HGNC:6667

Summary

The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence. [provided by RefSeq, Dec 2009]

RefSeq DNA

NG_016147.1

RefSeq mRNA

NM_005577.3, NM_005577.4

e!Ensembl

Gene	ENSG00000198670
Transcript	ENST00000316300, ENST00000614786, ENST00000447678
Protein	ENSP00000321334, ENSP00000480589, ENSP00000395608

Gene Ontology (GO)

Show/Hide all(11 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006629	Biological process	Lipid metabolic process	NAS	8047165
GO:0008015	Biological process	Blood circulation	TAS	8047165
GO:0005576	Cellular component	Extracellular region	NAS	14718574
GO:0034358	Cellular component	Plasma lipoprotein particle	IDA	2531657
GO:0001968	Molecular function	Fibronectin binding	IPI	2531657
GO:0004252	Molecular function	Serine-type endopeptidase activity	IBA	21873635
GO:0004252	Molecular function	Serine-type endopeptidase activity	IDA	2531657
GO:0004866	Molecular function	Endopeptidase inhibitor activity	TAS	8047165
GO:0005515	Molecular function	Protein binding	IPI	2531657, 9269765
GO:0008201	Molecular function	Heparin binding	NAS	2531657
GO:0034185	Molecular function	Apolipoprotein binding	IPI	9269765

Protein Information

Protein Name

Apolipoprotein(a), antiangiogenic AK38 protein, apo(a), lipoprotein, Lp(a), lp(a)

Function

Refseq Proteins

NP_005568.2

Pathways
	KEGG
	Cholesterol metabolism

Interactions

STRING	MINT	IntAct
ENSP00000417404	Q30201	Q30201

View interactions

Associated Diseases

Show/Hide all(5 )

Disease group	Disease Name	References
Cardiovascular Diseases
	Arteriosclerosis	23202125, 21378990, 20435227, 28714975, 29212778, 26343387
	Ischemic Cardiomyopathy	28714975
	Atherosclerosis	1465128, 17845920, 9770530
	Myocardial Infarction	28714975, 26343387
	Coronary heart disease	21966275, 21378990, 28753643, 24262325, 10484779
	Deep Vein Thrombosis	9164807
	Aortic valve calcification	23388002
	Aortic Valve Stenosis	29511194
	Acute Coronary Syndrome	28753643
Endocrine System Diseases
Endocrine System Diseases	PCOS	20137674
Neoplasms
Neoplasms	Lung Cancer	23103227
Nervous System Diseases
Nervous System Diseases	Stroke	10484779, 24262325
Nutritional and Metabolic Diseases
	Hypoprebetalipoproteinemia	10484779
	Lipoprotein A Deficiency	15523644
	Hypercholesterolemia	12697372

References

Show/Hide all(8)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
11720200	ApoB	Hyperandrogenemia,dyslipidemia and obesity			Related		The study confirms the trend toward dyslipidemia among women with PCOS, particularly in parameters associated with cardiovascular risk
10682453		Androgen excess and insulin resistance.			Related		The data suggest that altered lipid profiles in women with PCOS may result from the independent effects of androgen excess and insulin resistance
20426491	Granulosa cell biomarker				Related		This study suggests that ApoA-I can be useful as a granulosa cell biomarker of PCOS patients and that downregulated ApoA-I may be related to the disturbed production of steroid hormones in PCOS patients.
10593369	Lipoprotein phenotype B	Atherosclerosis		NIH criteria	Related	Hispanic women-16 PCOS & 21 controls	Hispanic women may have a higher incidence of the atherogenic lipoprotein phenotype B, which may increase their risk for atherosclerosis
9329374	APOB	Dyslipidemia,obesity, insulin resistance, and hyperandrogenemia		Rotterdam criteria	Related		When age, BMI, free androgen index, insulin sensitivity determined by all methods, and the presence of PCOS were subjected to stepwise multivariate regression analysis, the presence of PCOS was the most consistent predictor of lipid-depleted HDL (HDL total cholesterol/apoA-I and HDL phospholipids/apoA-I)
18056772	ApoB,SHBG	Cardiovascular risk,obesity, insulin resistance and hyperandrogenism		Rotterdam criteria	Related		PCOS is associated with a more pronounced atherogenic lipid profile.
20137674	ApoB	Hyperprolactinemia,infertility			Related		The PCOS women had reduced ApoB (680 + or - 230 nmol/L vs 943 + or - 179 mmol/L respectively) and Lpa level (46 + or - 22 nmol/L vs 162 + or - 194 mmol/L respectively) and high HOMA-IR when compared with non-hyperandrogenism PCOS
22703625	ET-1,Apo A1, Apo B,PON1,SHBG,DHEAS	Cardiovascular disease,insulin resistance, dyslipidemia, endothelial dysfunction, and oxidative stress			Related		The data show that insulin resistance, dyslipidemia, endothelial dysfunction, and oxidative stress might contribute to the excess risk of cardiovascular disease reported in PCOS patients