LPL: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

LPL

Aliases

HDLCQ11, LIPD

Entrez Gene ID

4023

Gene Name

Lipoprotein lipase

Chromosomal Location

8p21.3

HGNC ID

HGNC:6677

Summary

LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_008855.2

RefSeq mRNA

NM_000237.3

e!Ensembl

Gene	ENSG00000175445
Transcript	ENST00000520959, ENST00000524029, ENST00000522701, ENST00000650287, ENST00000519773, ENST00000650478
Protein	ENSP00000428496, ENSP00000428237, ENSP00000428557, ENSP00000497642, ENSP00000431028, ENSP00000497560

Gene Ontology (GO)

Show/Hide all(48 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006631	Biological process	Fatty acid metabolic process	IDA	11342582, 27578112
GO:0006633	Biological process	Fatty acid biosynthetic process	IBA	21873635
GO:0006633	Biological process	Fatty acid biosynthetic process	IC	3973011
GO:0006633	Biological process	Fatty acid biosynthetic process	IDA	182536
GO:0006641	Biological process	Triglyceride metabolic process	ISS	10727238
GO:0006644	Biological process	Phospholipid metabolic process	ISS	10727238
GO:0010744	Biological process	Positive regulation of macrophage derived foam cell differentiation	IC	12573449
GO:0010884	Biological process	Positive regulation of lipid storage	TAS	24608080
GO:0010886	Biological process	Positive regulation of cholesterol storage	IMP	12573449
GO:0010890	Biological process	Positive regulation of sequestering of triglyceride	IMP	12573449
GO:0016042	Biological process	Lipid catabolic process	IBA	21873635
GO:0019433	Biological process	Triglyceride catabolic process	IBA	21873635
GO:0019433	Biological process	Triglyceride catabolic process	IDA	182536, 2110364, 2340307, 3973011, 11342582, 27578112, 30559189
GO:0034371	Biological process	Chylomicron remodeling	IC	3973011
GO:0034371	Biological process	Chylomicron remodeling	IMP	11342582
GO:0034372	Biological process	Very-low-density lipoprotein particle remodeling	IBA	21873635
GO:0034372	Biological process	Very-low-density lipoprotein particle remodeling	IDA	3973011
GO:0034375	Biological process	High-density lipoprotein particle remodeling	IBA	21873635
GO:0042632	Biological process	Cholesterol homeostasis	IBA	21873635
GO:0042632	Biological process	Cholesterol homeostasis	IMP	25149060
GO:0045600	Biological process	Positive regulation of fat cell differentiation	IMP	29794473
GO:0050729	Biological process	Positive regulation of inflammatory response	IC	25149060
GO:0055096	Biological process	Low-density lipoprotein particle mediated signaling	IMP	25149060
GO:0070328	Biological process	Triglyceride homeostasis	IBA	21873635
GO:0070328	Biological process	Triglyceride homeostasis	IGI	17018885
GO:0090197	Biological process	Positive regulation of chemokine secretion	IMP	25149060
GO:0005615	Cellular component	Extracellular space	HDA	16502470
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IDA	2340307, 11342582, 12573449, 27578112, 30559189
GO:0004465	Molecular function	Lipoprotein lipase activity	IBA	21873635
GO:0004465	Molecular function	Lipoprotein lipase activity	IDA	2110364, 2340307, 3973011, 11342582, 27578112, 30559189
GO:0004465	Molecular function	Lipoprotein lipase activity	IMP	25149060
GO:0004465	Molecular function	Lipoprotein lipase activity	ISS	10727238
GO:0004620	Molecular function	Phospholipase activity	IBA	21873635
GO:0004620	Molecular function	Phospholipase activity	ISS	10727238
GO:0004806	Molecular function	Triglyceride lipase activity	IDA	182536, 12573449
GO:0004806	Molecular function	Triglyceride lipase activity	ISS	10727238
GO:0005102	Molecular function	Signaling receptor binding	IPI	10085125
GO:0005509	Molecular function	Calcium ion binding	IDA	16179346, 30559189
GO:0005515	Molecular function	Protein binding	IPI	20124439, 30559189
GO:0008201	Molecular function	Heparin binding	IDA	2110364, 11342582, 12573449
GO:0016298	Molecular function	Lipase activity	IBA	21873635
GO:0034185	Molecular function	Apolipoprotein binding	IBA	21873635
GO:0034185	Molecular function	Apolipoprotein binding	IPI	15178420
GO:0042803	Molecular function	Protein homodimerization activity	IDA	16179346
GO:0043395	Molecular function	Heparan sulfate proteoglycan binding	IMP	11342582
GO:0043495	Molecular function	Protein membrane anchor	TAS	24608080
GO:0071813	Molecular function	Lipoprotein particle binding	IDA	11342582

Protein Information

Protein Name

Lipoprotein lipase

Function

Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (PubMed:8675619, PubMed:11342582, PubMed:27578112). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (PubMed:24726386). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (PubMed:11342582, PubMed:27811232).

Refseq Proteins

NP_000228.1

UniProt

P06858

PDB

6E7K

Pfam

Pfam Accession	Pfam ID
PF00151	Lipase
PF01477	PLAT