LPO: Polycystic Ovarian Syndrome Database

LPO

Gene Information
 
Gene Symbol
LPO
 
Aliases
SPO
 
Entrez Gene ID
 
Gene Name
Lactoperoxidase
 
Chromosomal Location
17q22
 
HGNC ID
 
Summary
This gene encodes a member of the peroxidase family of proteins. The encoded preproprotein is proteolytically processed to generate the mature enzyme. Following its secretion from salivary, mammary, and other mucosal glands, this enzyme catalyzes the generation of the antimicrobial substance hypothiocyanous acid. This gene is present in a gene cluster on chromosome 17. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0001580 Biological process Detection of chemical stimulus involved in sensory perception of bitter taste IDA 24248522
GO:0006979 Biological process Response to oxidative stress NAS 8964511
GO:0042742 Biological process Defense response to bacterium IBA 21873635
GO:0042742 Biological process Defense response to bacterium IDA 12626341
GO:0005615 Cellular component Extracellular space IBA 21873635
Protein Information
 
Protein Name
Lactoperoxidase, salivary peroxidase
 
Function
Antimicrobial agent which utilizes hydrogen peroxide and thiocyanate (SCN) to generate the antimicrobial substance hypothiocyanous acid (HOSCN) (By similarity). May contribute to airway host defense against infection.
 
UniProt
 
Pfam
Pfam Accession Pfam ID
PF03098 An_peroxidase
Pathways
 
KEGG
 
Reactome
 

Salivary secretion

  

Events associated with phagocytolytic activity of PMN cells
Interactions
 
STRING MINT IntAct
ENSP00000250896 Q9HBH9
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Cystic Fibrosis
Endocrine System Diseases
PCOS
Immune System Diseases
Graft-vs-Host Disease
References
 
 
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
PCOS, Abdominal obesity, insulin resistance , adrenal hyperandrogenism 
 
 Rotterdam 2004 criteria 
Related 
80 women younger than 37 years old  
 Abdominal obesity can induce local and systemic oxidative stress in PCOS and non-PCOS patients. We suggest that PCOS-induced disorders are likely to be exacerbated in the presence of abdominal obesity. 
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