LUM: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

LUM

Aliases

LDC, SLRR2D

Entrez Gene ID

4060

Gene Name

Lumican

Chromosomal Location

12q21.33

HGNC ID

HGNC:6724

Summary

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. [provided by RefSeq, Jul 2008]

e!Ensembl

Gene	ENSG00000139329
Transcript	ENST00000266718
Protein	ENSP00000266718

Gene Ontology (GO)

Show/Hide all(15 )

GO ID	Ontology	Function	Evidence	Reference
GO:0030199	Biological process	Collagen fibril organization	NAS	10892350
GO:0005576	Cellular component	Extracellular region	HDA	27068509
GO:0005576	Cellular component	Extracellular region	NAS	14718574
GO:0005583	Cellular component	Fibrillar collagen trimer	IDA	10734230
GO:0005615	Cellular component	Extracellular space	HDA	20551380
GO:0031012	Cellular component	Extracellular matrix	TAS	7665616
GO:0062023	Cellular component	Collagen-containing extracellular matrix	HDA	25037231, 27559042, 28675934
GO:0062023	Cellular component	Collagen-containing extracellular matrix	HDA	20551380
GO:0062023	Cellular component	Collagen-containing extracellular matrix	ISS	22261194
GO:0070062	Cellular component	Extracellular exosome	HDA	23533145
GO:0005201	Molecular function	Extracellular matrix structural constituent	NAS	10892350
GO:0005515	Molecular function	Protein binding	IPI	25304424
GO:0005518	Molecular function	Collagen binding	IBA	21873635
GO:0005518	Molecular function	Collagen binding	IDA	10892350
GO:0030021	Molecular function	Extracellular matrix structural constituent conferring compression resistance	RCA	20551380, 25037231, 27559042, 28675934

Protein Information

Protein Name

Lumican, KSPG lumican, epididymis secretory sperm binding protein, keratan sulfate proteoglycan lumican, lumican proteoglycan

Function

UniProt

P51884

Pfam

Pfam Accession	Pfam ID
PF13516	LRR_6
PF13855	LRR_8
PF01462	LRRNT