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Gene Information   Gene Symbol LY6E   Aliases RIG-E, RIGE, SCA-2, SCA2, TSA-1   Entrez Gene ID 4061   Gene Name Lymphocyte antigen 6 family member E   Chromosomal Location 8q24.3   HGNC ID HGNC:6727   e!Ensembl Gene ENSG00000278032, ENSG00000160932 Transcript ENST00000633898, ENST00000619718, ENST00000632424, ENST00000632519, ENST00000633934, ENST00000632812, ENST00000632516, ENST00000632232, ENST00000631568, ENST00000632902, ENST00000632978, ENST00000632618, ENST00000633551, ENST00000633451, ENST00000517503, ENST00000292494, ENST00000429120, ENST00000521699, ENST00000520531, ENST00000520466, ENST00000521003, ENST00000522528, ENST00000522971, ENST00000519611, ENST00000521182, ENST00000519546, ENST00000523847, ENST00000522024   Protein ENSP00000488311, ENSP00000482517, ENSP00000488421, ENSP00000488443, ENSP00000488115, ENSP00000488556, ENSP00000487664, ENSP00000488743, ENSP00000488891, ENSP00000488121, ENSP00000488414, ENSP00000487700, ENSP00000488627, ENSP00000488559, ENSP00000428427, ENSP00000292494, ENSP00000414307, ENSP00000427915, ENSP00000430131, ENSP00000428572, ENSP00000428169, ENSP00000428365, ENSP00000428159, ENSP00000430796, ENSP00000430770, ENSP00000428467, ENSP00000430700, ENSP00000428442 Gene Ontology (GO) Show/Hide all(5 ) GO ID Ontology Function Evidence Reference GO:0007166 Biological process Cell surface receptor signaling pathway TAS 8650192 GO:0005886 Cellular component Plasma membrane IBA 21873635 GO:0016020 Cellular component Membrane IBA 21873635 GO:0031225 Cellular component Anchored component of membrane IBA 21873635 GO:0030550 Molecular function Acetylcholine receptor inhibitor activity IBA 21873635 Protein Information   Protein Name Lymphocyte antigen 6E, ly-6E, lymphocyte antigen 6 complex, locus E, retinoic acid induced gene E, retinoic acid-induced gene E protein, stem cell antigen 2, thymic shared antigen 1   Function Involved in T-cell development. Believed to act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response   UniProt Q16553   Pfam Pfam Accession Pfam ID PF00021 UPAR_LY6 Pathways   Reactome     Post-translational modification: synthesis of GPI-anchored proteins Interactions   STRING MINT IntAct ENSP00000428572 Q16553     View interactions       Associated Diseases Show/Hide all(5 ) Disease group Disease Name References Endocrine System Diseases PCOS 29262729 Immune System Diseases Lupus Erythematosus 26568589, 21239754 Rheumatoid Arthritis 22540992 Neoplasms Gastric Cancer 29448250 Breast Cancer 27197181 Neoplasms 25862760 Genitourinary Cancer 30089113 Esophagus Neoplasm 26785143 Multiple Sclerosis 21886806 Lung Cancer 22710433 Nervous System Diseases Transient Ischemic Attack 29284304 Systemic Lupus Erythematosus 29321042, 27230555, 25344775, 24064706 Respiratory Tract Diseases Respiratory Distress Syndrome 30665420 References     Show/Hide all(1) PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion 29262729    PCOS, Inflammation    Rotterdam Criteria  Direct  8 PCOS Subjects and 8 Controls  We conducted the peripheral-blood transcriptome in PCOS using microarray and identified dysregulated genes involved in inflammatory response. Our data strongly supported the notion that systemic rather than a local inflammatory response is implicated in the etiology of PCOS.

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