LYN: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

LYN

Aliases

JTK8, p53Lyn, p56Lyn

Entrez Gene ID

4067

Gene Name

LYN proto-oncogene, Src family tyrosine kinase

Chromosomal Location

8q12.1

HGNC ID

HGNC:6735

Summary

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

RefSeq DNA

NG_029593.1

RefSeq mRNA

NM_002350.4, NM_001111097.3

e!Ensembl

Gene	ENSG00000254087
Transcript	ENST00000519728, ENST00000520220, ENST00000520050
Protein	ENSP00000428924, ENSP00000428424, ENSP00000428313

Gene Ontology (GO)

Show/Hide all(52 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001932	Biological process	Regulation of protein phosphorylation	TAS	15489917
GO:0001934	Biological process	Positive regulation of protein phosphorylation	IGI	24217950
GO:0002431	Biological process	Fc receptor mediated stimulatory signaling pathway	IBA	21873635
GO:0002513	Biological process	Tolerance induction to self antigen	IBA	21873635
GO:0002513	Biological process	Tolerance induction to self antigen	TAS	15489917
GO:0002576	Biological process	Platelet degranulation	IBA	21873635
GO:0002768	Biological process	Immune response-regulating cell surface receptor signaling pathway	TAS	15489917
GO:0002902	Biological process	Regulation of B cell apoptotic process	IBA	21873635
GO:0006468	Biological process	Protein phosphorylation	IDA	11517336
GO:0006974	Biological process	Cellular response to DNA damage stimulus	IBA	21873635
GO:0006974	Biological process	Cellular response to DNA damage stimulus	IDA	10891478, 11517336
GO:0007165	Biological process	Signal transduction	TAS	7650013
GO:0007169	Biological process	Transmembrane receptor protein tyrosine kinase signaling pathway	IBA	21873635
GO:0007169	Biological process	Transmembrane receptor protein tyrosine kinase signaling pathway	IMP	14726379
GO:0008285	Biological process	Negative regulation of cell proliferation	IMP	14726379
GO:0010976	Biological process	Positive regulation of neuron projection development	IMP	17910947
GO:0018108	Biological process	Peptidyl-tyrosine phosphorylation	IDA	7682714, 11782428
GO:0030154	Biological process	Cell differentiation	IBA	21873635
GO:0030889	Biological process	Negative regulation of B cell proliferation	IBA	21873635
GO:0031175	Biological process	Neuron projection development	IBA	21873635
GO:0033628	Biological process	Regulation of cell adhesion mediated by integrin	IMP	18802065
GO:0038083	Biological process	Peptidyl-tyrosine autophosphorylation	IBA	21873635
GO:0043304	Biological process	Regulation of mast cell degranulation	IBA	21873635
GO:0046777	Biological process	Protein autophosphorylation	IDA	7682714
GO:0050777	Biological process	Negative regulation of immune response	TAS	15489917
GO:0050855	Biological process	Regulation of B cell receptor signaling pathway	IBA	21873635
GO:0051272	Biological process	Positive regulation of cellular component movement	IDA	16467205
GO:0070304	Biological process	Positive regulation of stress-activated protein kinase signaling cascade	IDA	10891478
GO:0070667	Biological process	Negative regulation of mast cell proliferation	IBA	21873635
GO:0070668	Biological process	Positive regulation of mast cell proliferation	IMP	11435302
GO:0071300	Biological process	Cellular response to retinoic acid	IMP	17910947
GO:0090025	Biological process	Regulation of monocyte chemotaxis	IMP	18802065
GO:0090330	Biological process	Regulation of platelet aggregation	IBA	21873635
GO:0097028	Biological process	Dendritic cell differentiation	IBA	21873635
GO:1902961	Biological process	Positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process	IMP	24217950
GO:2000670	Biological process	Positive regulation of dendritic cell apoptotic process	IBA	21873635
GO:0005634	Cellular component	Nucleus	IDA	18817770
GO:0005794	Cellular component	Golgi apparatus	IDA	15173188, 20605918
GO:0005886	Cellular component	Plasma membrane	IDA	15173188, 20605918
GO:0031234	Cellular component	Extrinsic component of cytoplasmic side of plasma membrane	IBA	21873635
GO:0045121	Cellular component	Membrane raft	IDA	11313396
GO:0048471	Cellular component	Perinuclear region of cytoplasm	IDA	20605918
GO:0070062	Cellular component	Extracellular exosome	HDA	23533145
GO:0004713	Molecular function	Protein tyrosine kinase activity	EXP	1381360, 7526393, 9799234, 11358993, 11448999, 12670955, 12923167, 18697750
GO:0004713	Molecular function	Protein tyrosine kinase activity	IDA	7682714, 10748115
GO:0004715	Molecular function	Non-membrane spanning protein tyrosine kinase activity	IBA	21873635
GO:0005102	Molecular function	Signaling receptor binding	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	1715582, 7859737, 8647200, 8753773, 9020138, 11306681, 11517336, 14993658, 15546919, 15784897, 16155203, 16799092, 17254966, 17640867, 18070987, 19940238, 20037584, 20159608, 22581261, 22624718, 22731636, 23001182, 23764002, 23866081, 24658140, 24728074
GO:0016301	Molecular function	Kinase activity	NAS	24217950
GO:0044325	Molecular function	Ion channel binding	IPI	12538589
GO:0046875	Molecular function	Ephrin receptor binding	IPI	24217950
GO:0140031	Molecular function	Phosphorylation-dependent protein binding	IPI	11782428

Protein Information

Protein Name

Tyrosine-protein kinase Lyn, lck/Yes-related novel protein tyrosine kinase, v-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Function

Refseq Proteins

NP_002341.1, NP_001104567.1

UniProt

P07948

PDB

1W1F, 1WA7, 3A4O, 5XY1, 6NMW

Pfam

Pfam Accession	Pfam ID
PF07714	Pkinase_Tyr
PF00017	SH2
PF00018	SH3_1