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Gene Symbol |
MAOA |
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Aliases |
BRNRS, MAO-A |
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Entrez Gene ID |
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Gene Name |
Monoamine oxidase A |
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Chromosomal Location |
Xp11.3 |
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HGNC ID |
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Summary |
This gene is one of two neighboring gene family members that encode mitochondrial enzymes which catalyze the oxidative deamination of amines, such as dopamine, norepinephrine, and serotonin. Mutation of this gene results in Brunner syndrome. This gene has also been associated with a variety of other psychiatric disorders, including antisocial behavior. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]
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RefSeq DNA |
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RefSeq mRNA |
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e!Ensembl
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| Protein Information |
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Protein Name |
Amine oxidase [flavin-containing] A, monoamine oxidase type A |
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Function |
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Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine |
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UniProt |
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PDB |
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Pfam |
| Pfam Accession |
Pfam ID |
| PF01593 |
Amino_oxidase |
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Interactions |
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| STRING |
MINT |
IntAct |
| ENSP00000340684 |
P21397 |
P21397 |
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View interactions
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Associated Diseases
| Disease group | Disease Name | References |
| Blood Disorders |
| Kawasaki disease |
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| Lymphadenitis |
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| Hypotension |
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| Cardiovascular Diseases |
| Cardiovascular Abnormalities |
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| Hypertensive disease |
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| Heart Failure |
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| Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
| Nail patella syndrome |
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| Developmental Delay |
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| Tourette syndrome |
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| Congenital Abnormality |
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| Mental Retardation |
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| Digestive System Diseases |
| Liver Failure |
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| Endocrine System Diseases |
| PCOS |
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| Diabetes Mellitus |
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| Eye Diseases |
| Norrie disease |
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| Immune System Diseases |
| Allergic rhinitis |
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| Musculoskeletal Diseases |
| Myopathy |
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| Temporomandibular Joint Disorders |
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| Neoplasms |
| Lung Cancer |
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| Neuroblastoma |
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| Glioblastoma |
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| Liver Cancer |
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| Pheochromocytoma |
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| Breast Cancer |
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| Esophagus Neoplasm |
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| Erdheim-Chester disease |
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| Pancreatic Neoplasm |
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| Leukemia |
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| Nervous System Diseases |
| Dyskinesia |
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| Migraine |
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| Epilepsy |
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| Lateral Sclerosis |
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| Degenerative Diseases Central Nervous System |
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| Stroke |
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| Dementia |
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| Cerebrovascular Disorders |
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| Nutritional and Metabolic Diseases |
| Deficiency Diseases |
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| Hepatic Encephalopathy |
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| Obesity |
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| Psychiatric/Brain disorders |
| Seasonal Affective Disorder |
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| Mood Disorders |
29568754, 16319504, 21422455, 10591056, 24898155, 18463263, 21810646, 16890910, 9342198, 20967566, 12527023, 17137563, 26481676, 11920860 |
| Mental Depression |
25412041, 23197705, 25655492, 28109809, 26821818, 30635228, 27840401, 25074638, 9564606, 28068665, 26299850, 24809685, 19890267, 22382901, 23707423, 27558674, 3432361, 22948532, 23018753, 22619623, 11121185, 21463543, 8313394, 19996035, 17088501, 18337637, 15486489, 19214141, 204398 |
| Neurodevelopmental Disorders |
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| Autistic Disorder |
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| Neurocognitive Disorders |
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| Narcolepsy |
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| Behavior Disorders |
26081301, 21832987, 16741202, 1638170, 25082653, 17943028, 17007976, 17406964, 1323180, 18566955, 8313403, 7913851, 29855796, 18569727, 19572987, 24971323, 25637908, 19168625 |
| Attention Deficit Disorder |
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| Brunner syndrome |
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| Schizophrenia |
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| Borderline Personality Disorder |
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| Sleep Disorders |
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| Panic Disorder |
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| Anxiety Disorders |
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| Senile Dementia |
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| Obsessive Compulsive Disorder |
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| Bipolar Disorder |
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| Cognition Disorders |
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| Learning Disorders |
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| Psychosis |
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| Pain Disorder |
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| Diagnosis, Psychiatric |
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| Neuroticism |
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| Restless Legs Syndrome |
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| Respiratory Tract Diseases |
| Asthma |
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| Skin and Connective Tissue Diseases |
| Eczema |
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References |
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| PubMed ID |
Associated gene/s |
Associated condition |
Genetic Mutation |
Diagnostic Criteria |
Association with PCOS |
Ethnicity |
Conclusion |
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PCOS, Dopamine Metabolism |
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Rotterdam Criteria |
Direct
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3 PCOS patients and 3 non- PCOS patients |
LGCs from PCOS cells treated with Cb2 present more significant changes at the transcriptomiclevel than non-PCOS cells. To validate whether there were significant differences between Cb2-treated and -untreated samples, seven key genes were selected by GSEA analysis, The RT-qPCR results for all validated genes showed the same trend as found in the microarray experiment, confirming the microarray data. In addition, most of the changes were significant (P value <0.05). |
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