MAPK14: Polycystic Ovarian Syndrome Database

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MAPK14

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

MAPK14

Aliases

CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA

Entrez Gene ID

1432

Gene Name

Mitogen-activated protein kinase 14

Chromosomal Location

6p21.31

HGNC ID

HGNC:6876

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

e!Ensembl

Gene	ENSG00000112062
Transcript	ENST00000229795, ENST00000229794, ENST00000468133, ENST00000491957, ENST00000310795, ENST00000474429, ENST00000472333, ENST00000622903
Protein	ENSP00000229795, ENSP00000229794, ENSP00000419837, ENSP00000417531, ENSP00000308669, ENSP00000417065, ENSP00000419141, ENSP00000478079

Gene Ontology (GO)

Show/Hide all(33 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006935	Biological process	Chemotaxis	TAS	10706854
GO:0007165	Biological process	Signal transduction	TAS	10706854
GO:0007166	Biological process	Cell surface receptor signaling pathway	TAS	10706854
GO:0010468	Biological process	Regulation of gene expression	IBA	21873635
GO:0010628	Biological process	Positive regulation of gene expression	IGI	24299952
GO:0010628	Biological process	Positive regulation of gene expression	IMP	25754930, 26649771
GO:0031281	Biological process	Positive regulation of cyclase activity	IMP	22027397
GO:0035556	Biological process	Intracellular signal transduction	IBA	21873635
GO:0035556	Biological process	Intracellular signal transduction	IDA	10838079
GO:0035924	Biological process	Cellular response to vascular endothelial growth factor stimulus	IMP	18440775
GO:0042770	Biological process	Signal transduction in response to DNA damage	IMP	20160708
GO:0043536	Biological process	Positive regulation of blood vessel endothelial cell migration	IMP	18440775
GO:0045648	Biological process	Positive regulation of erythrocyte differentiation	IMP	23483889
GO:0048010	Biological process	Vascular endothelial growth factor receptor signaling pathway	IMP	18440775
GO:0070935	Biological process	3'-UTR-mediated mRNA stabilization	TAS	20932473
GO:0071222	Biological process	Cellular response to lipopolysaccharide	IDA	23776175
GO:0071223	Biological process	Cellular response to lipoteichoic acid	IMP	26649771
GO:0071310	Biological process	Cellular response to organic substance	IBA	21873635
GO:0071479	Biological process	Cellular response to ionizing radiation	IMP	20160708
GO:0090400	Biological process	Stress-induced premature senescence	IMP	20160708
GO:0098586	Biological process	Cellular response to virus	IMP	25754930
GO:1900015	Biological process	Regulation of cytokine production involved in inflammatory response	IDA	15251176
GO:2000379	Biological process	Positive regulation of reactive oxygen species metabolic process	IMP	20160708
GO:2001184	Biological process	Positive regulation of interleukin-12 secretion	IMP	25754930
GO:0005634	Cellular component	Nucleus	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IBA	21873635
GO:0004707	Molecular function	MAP kinase activity	IBA	21873635
GO:0004707	Molecular function	MAP kinase activity	IDA	7997261, 10330143, 20932473
GO:0004708	Molecular function	MAP kinase kinase activity	TAS	10706854
GO:0005515	Molecular function	Protein binding	IPI	9792677, 10601328, 11238443, 16189514, 16751104, 17255097, 17255949, 17380123, 17380128, 18624398, 20347885, 20368287, 20871633, 20936779, 21283629, 21900206, 21908610, 21988832, 22521293, 23397142, 23455922, 23560844, 23602568, 25241761, 25852190, 26496610
GO:0019899	Molecular function	Enzyme binding	IPI	23483889
GO:0019903	Molecular function	Protein phosphatase binding	IPI	10391943, 21283629
GO:0048273	Molecular function	Mitogen-activated protein kinase p38 binding	IPI	11035004

Protein Information

Protein Name

Mitogen-activated protein kinase 14, CSAID-binding protein, MAP kinase 14, MAP kinase Mxi2, MAP kinase p38 alpha, MAX-interacting protein 2, cytokine suppressive anti-inflammatory drug binding protein, mitogen-activated protein kinase p38 alpha, p38 MAP kinase, p38 mitogen activated protein kinase, p38alpha Exip, stress-activated protein kinase 2A

Function

UniProt

Q16539

PDB

2OKR, 2ONL, 1A9U, 1BL6, 1BL7, 1BMK, 1DI9, 1IAN, 1KV1, 1KV2, 1M7Q, 1OUK, 1OUY, 1OVE, 1OZ1, 1R39, 1R3C, 1W7H, 1W82, 1W83, 1W84, 1WBN, 1WBO, 1WBS, 1WBT, 1WBV, 1WBW, 1WFC, 1YQJ, 1ZYJ, 1ZZ2, 1ZZL, 2BAJ, 2BAK, 2BAL, 2BAQ, 2FSL, 2FSM, 2FSO, 2FST, 2GFS, 2I0H, 2LGC, 2NPQ, 2QD9, 2RG5, 2RG6, 2Y8O, 2YIS, 2YIW, 2YIX,

Pathways
	KEGG	Reactome
	Endocrine resistance MAPK signaling pathway Rap1 signaling pathway FoxO signaling pathway Sphingolipid signaling pathway Cellular senescence Adrenergic signaling in cardiomyocytes VEGF signaling pathway Osteoclast differentiation Signaling pathways regulating pluripotency of stem cells Platelet activation Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway C-type lectin receptor signaling pathway IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Fc epsilon RI signaling pathway TNF signaling pathway Leukocyte transendothelial migration Thermogenesis Neurotrophin signaling pathway Retrograde endocannabinoid signaling Dopaminergic synapse Inflammatory mediator regulation of TRP channels GnRH signaling pathway Progesterone-mediated oocyte maturation Prolactin signaling pathway Relaxin signaling pathway AGE-RAGE signaling pathway in diabetic complications Amyotrophic lateral sclerosis (ALS) Epithelial cell signaling in Helicobacter pylori infection Shigellosis Salmonella infection Pertussis Yersinia infection Leishmaniasis Chagas disease (American trypanosomiasis) Toxoplasmosis Tuberculosis Hepatitis B Human cytomegalovirus infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Proteoglycans in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Fluid shear stress and atherosclerosis	NOD1/2 Signaling Pathway p38MAPK events ERK/MAPK targets Oxidative Stress Induced Senescence DSCAM interactions ADP signalling through P2Y purinoceptor 1 Platelet sensitization by LDL VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors Myogenesis RHO GTPases Activate NADPH Oxidases Neutrophil degranulation Regulation of TP53 Activity through Phosphorylation CD163 mediating an anti-inflammatory response

Interactions

STRING	MINT	IntAct
ENSP00000284503		Q969S2

View interactions

Associated Diseases

Show/Hide all(6 )

Disease group	Disease Name	References
Cardiovascular Diseases
	Cardiomyopathy	10620750
	Diabetic Foot	28672053
	Myocardial Ischemia	16214533
	Myocardial Diseases	10620750
Digestive System Diseases
Digestive System Diseases	Cholestasis	20626112
Endocrine System Diseases
	Diabetes Mellitus	28672053
	PCOS	27997581
Neoplasms
	Myeloid Leukemia	16818652
	Liver Cancer	17468757
	Lung Cancer	17468755
Nervous System Diseases
Nervous System Diseases	Neuropathy	28672053
Psychiatric/Brain disorders
	Mental Depression	21356304
	Schizophrenia	18460190
	Mood Disorders	17959804

References

PMID: 27997581

Identification of Polycystic Ovary Syndrome (PCOS) Specific Genes in Cumulus and Mural Granulosa Cells.

Aydos Alp, Gurel Aykut, Oztemur Islakoglu Yasemin, Noyan Senem, Gokce Bagdagul, Ecemis Tolga, Kaya Cemil, Aksu Arif Tarik, Gur Dedeoglu Bala

Biotechnology Institute, Ankara University, Ankara, Turkey.| Test Tube Babies Unit, HRS Women Hospital, Ankara, Turkey.| Biotechnology Institute, Ankara University, Ankara, Turkey.| Biotechnology Institute, Ankara University, Ankara, Turkey.| Test Tube Babies Unit, Medicana International Ankara Hospital, Ankara, Turkey.| Department of Gynecology and Obstetrics, Liv Hospital, Ankara, Turkey.| Department of Gynecology and Obstetrics, TOBB ETU Hospital, Ankara, Turkey.| Department of Gynecology and Obstetrics, HRS Women Hospital, Ankara, Turkey.| Biotechnology Institute, Ankara University, Ankara, Turkey.

PLoS One. 2016 Dec 20;11(12):e0168875. doi: 10.1371/journal.pone.0168875.

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