MAPK9: Polycystic Ovarian Syndrome Database

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MAPK9

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

MAPK9

Aliases

JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK

Entrez Gene ID

5601

Gene Name

Mitogen-activated protein kinase 9

Chromosomal Location

5q35.3

HGNC ID

HGNC:6886

Summary

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this gene's mouse counterpart suggest a key role in T-cell differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Sep 2008]

RefSeq DNA

NG_029059.1

RefSeq mRNA

NM_002752.5, NM_139068.3, NM_139069.3, NM_139070.3, NM_001135044.2, NM_001308244.1, NM_001364607.2, NM_001364608.2, NM_001364609.2, NM_001364610.2, NM_001364611.2, NM_001364612.1, NM_001364613.2

e!Ensembl

Gene	ENSG00000050748
Transcript	ENST00000452135, ENST00000393360, ENST00000455781, ENST00000343111, ENST00000347470, ENST00000393362, ENST00000425491, ENST00000523583, ENST00000539014, ENST00000397072
Protein	ENSP00000394560, ENSP00000377028, ENSP00000389338, ENSP00000345524, ENSP00000321410, ENSP00000377029, ENSP00000397422, ENSP00000430608, ENSP00000443149, ENSP00000380262

Gene Ontology (GO)

Show/Hide all(20 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006468	Biological process	Protein phosphorylation	IMP	22441692
GO:0007254	Biological process	JNK cascade	IDA	8654373
GO:0009612	Biological process	Response to mechanical stimulus	IBA	21873635
GO:0010468	Biological process	Regulation of gene expression	IBA	21873635
GO:0010628	Biological process	Positive regulation of gene expression	IMP	18262097
GO:0010744	Biological process	Positive regulation of macrophage derived foam cell differentiation	IMP	18262097
GO:0018105	Biological process	Peptidyl-serine phosphorylation	IDA	21856198
GO:0034614	Biological process	Cellular response to reactive oxygen species	IMP	26514923
GO:0035556	Biological process	Intracellular signal transduction	IBA	21873635
GO:0043065	Biological process	Positive regulation of apoptotic process	IBA	21873635
GO:0048666	Biological process	Neuron development	IBA	21873635
GO:0071276	Biological process	Cellular response to cadmium ion	IMP	26514923
GO:0071310	Biological process	Cellular response to organic substance	IBA	21873635
GO:0005634	Cellular component	Nucleus	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IBA	21873635
GO:0043005	Cellular component	Neuron projection	IBA	21873635
GO:0004705	Molecular function	JUN kinase activity	IDA	8654373
GO:0004707	Molecular function	MAP kinase activity	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	10376527, 15158451, 16189514, 16288922, 19060904, 20871632, 21988832, 25241761, 25416956, 28089251
GO:0008134	Molecular function	Transcription factor binding	IDA	10376527

Protein Information

Protein Name

Mitogen-activated protein kinase 9, Jun kinase, MAP kinase 9, MAPK 9, c-Jun N-terminal kinase 2, c-Jun kinase 2, stress-activated protein kinase 1a, stress-activated protein kinase JNK2

Function

Refseq Proteins

NP_002743.3, NP_620707.1, NP_620708.1, NP_620709.1, NP_001128516.1, NP_001295173.1, NP_001351536.1, NP_001351537.1, NP_001351538.1, NP_001351539.1, NP_001351540.1, NP_001351541.1, NP_001351542.1

UniProt

P45984

PDB

3E7O, 3NPC

Pathways
	KEGG	Reactome
	Endocrine resistance MAPK signaling pathway ErbB signaling pathway Ras signaling pathway cAMP signaling pathway FoxO signaling pathway Sphingolipid signaling pathway Mitophagy - animal Autophagy - animal Protein processing in endoplasmic reticulum Apoptosis Apoptosis - multiple species Necroptosis Wnt signaling pathway Osteoclast differentiation Focal adhesion Tight junction Toll-like receptor signaling pathway NOD-like receptor signaling pathway RIG-I-like receptor signaling pathway C-type lectin receptor signaling pathway IL-17 signaling pathway Th1 and Th2 cell differentiation Th17 cell differentiation T cell receptor signaling pathway Fc epsilon RI signaling pathway TNF signaling pathway Neurotrophin signaling pathway Retrograde endocannabinoid signaling Dopaminergic synapse Inflammatory mediator regulation of TRP channels Insulin signaling pathway GnRH signaling pathway Progesterone-mediated oocyte maturation Prolactin signaling pathway Adipocytokine signaling pathway Relaxin signaling pathway Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease (NAFLD) AGE-RAGE signaling pathway in diabetic complications Epithelial cell signaling in Helicobacter pylori infection Shigellosis Salmonella infection Pertussis Yersinia infection Chagas disease (American trypanosomiasis) Toxoplasmosis Tuberculosis Hepatitis B Measles Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Colorectal cancer Pancreatic cancer Choline metabolism in cancer Fluid shear stress and atherosclerosis	Oxidative Stress Induced Senescence FCERI mediated MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Activation of the AP-1 family of transcription factors

Interactions

STRING	MINT	IntAct
ENSP00000226574	P19838	P19838

View interactions

Associated Diseases

Show/Hide all(4 )

Disease group	Disease Name	References
Digestive System Diseases
Digestive System Diseases	Cholestasis	28789951
Endocrine System Diseases
Endocrine System Diseases	PCOS	29030491
Nervous System Diseases
Nervous System Diseases	Trigeminal neuralgia	27093858
Psychiatric/Brain disorders
Psychiatric/Brain disorders	Obstructive Sleep Apnea	29992456

References

PMID: 29030491

Autophagy is activated in the ovarian tissue of polycystic ovary syndrome.

Li Da, You Yue, Bi Fang-Fang, Zhang Tie-Ning, Jiao Jiao, Wang Tian-Ren, Zhou Yi-Ming, Shen Zi-Qi, Wang Xiu-Xia, Yang Qing

Center of Reproductive MedicineShengjing Hospital of China Medical University, Shenyang, China.| Department of Obstetrics and GynecologyShengjing Hospital of China Medical University, Shenyang, China.| Department of Obstetrics and GynecologyShengjing Hospital of China Medical University, Shenyang, China.| Department of PediatricsShengjing Hospital of China Medical University, Shenyang, China.| Center of Reproductive MedicineShengjing Hospital of China Medical University, Shenyang, China.| Center of Reproductive MedicineShengjing Hospital of China Medical University, Shenyang, China.| Department of ObstetricsGynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, USA.| Department of MedicineBrigham and Women's Hospital, Harvard Institutes of Medicine, Harvard Medical School, Boston, Massachusetts, USA.| Center of Reproductive MedicineShengjing Hospital of China Medical University, Shenyang, China.| Center of Reproductive MedicineShengjing Hospital of China Medical University, Shenyang, China yangq@sj-hospital.org wangxxsj@sina.cn.| Department of Obstetrics and GynecologyShengjing Hospital of China Medical University, Shenyang, China yangq@sj-hospital.org wangxxsj@sina.cn.

Reproduction. 2018 Jan;155(1):85-92. doi: 10.1530/REP-17-0499. Epub 2017 Oct 13.

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