MIF: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

MIF

Aliases

GIF, GLIF, MMIF

Entrez Gene ID

4282

Gene Name

Macrophage migration inhibitory factor

Chromosomal Location

22q11.23

HGNC ID

HGNC:7097

Summary

This gene encodes a lymphokine involved in cell-mediated immunity, immunoregulation, and inflammation. It plays a role in the regulation of macrophage function in host defense through the suppression of anti-inflammatory effects of glucocorticoids. This lymphokine and the JAB1 protein form a complex in the cytosol near the peripheral plasma membrane, which may indicate an additional role in integrin signaling pathways. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_012099.1

RefSeq mRNA

NM_002415.2

e!Ensembl

Gene	ENSG00000240972, ENSG00000276701
Transcript	ENST00000215754, ENST00000613839
Protein	ENSP00000215754, ENSP00000482779

Gene Ontology (GO)

Show/Hide all(38 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001516	Biological process	Prostaglandin biosynthetic process	IDA	12782713
GO:0007166	Biological process	Cell surface receptor signaling pathway	IDA	12782713
GO:0008283	Biological process	Cell proliferation	IDA	12782713
GO:0010629	Biological process	Negative regulation of gene expression	IDA	10562313
GO:0010739	Biological process	Positive regulation of protein kinase A signaling	IDA	17045821
GO:0010760	Biological process	Negative regulation of macrophage chemotaxis	IDA	21817065
GO:0019752	Biological process	Carboxylic acid metabolic process	IDA	12782713
GO:0030890	Biological process	Positive regulation of B cell proliferation	IDA	12782713
GO:0032760	Biological process	Positive regulation of tumor necrosis factor production	IDA	21817065
GO:0033138	Biological process	Positive regulation of peptidyl-serine phosphorylation	IDA	17045821
GO:0042327	Biological process	Positive regulation of phosphorylation	IDA	12782713
GO:0043030	Biological process	Regulation of macrophage activation	NAS	12782713
GO:0043066	Biological process	Negative regulation of apoptotic process	IDA	12782713
GO:0043518	Biological process	Negative regulation of DNA damage response, signal transduction by p53 class mediator	IDA	17045821
GO:0048146	Biological process	Positive regulation of fibroblast proliferation	IDA	12782713
GO:0050715	Biological process	Positive regulation of cytokine secretion	IDA	19602265
GO:0050731	Biological process	Positive regulation of peptidyl-tyrosine phosphorylation	IDA	17045821
GO:0070207	Biological process	Protein homotrimerization	IPI	17526494
GO:0070374	Biological process	Positive regulation of ERK1 and ERK2 cascade	IDA	12782713, 17045821
GO:0070374	Biological process	Positive regulation of ERK1 and ERK2 cascade	IGI	21817065
GO:0071157	Biological process	Negative regulation of cell cycle arrest	IDA	10562313
GO:0090344	Biological process	Negative regulation of cell aging	IDA	10562313
GO:1902166	Biological process	Negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator	IDA	17045821
GO:0005576	Cellular component	Extracellular region	HDA	27068509
GO:0005576	Cellular component	Extracellular region	IDA	12782713
GO:0005615	Cellular component	Extracellular space	IDA	21817065
GO:0009986	Cellular component	Cell surface	IDA	12782713
GO:0031982	Cellular component	Vesicle	HDA	19190083
GO:0070062	Cellular component	Extracellular exosome	HDA	19056867, 20458337, 23533145
GO:0004167	Molecular function	Dopachrome isomerase activity	IDA	17526494
GO:0005102	Molecular function	Signaling receptor binding	IPI	12782713
GO:0005125	Molecular function	Cytokine activity	IDA	12782713
GO:0005126	Molecular function	Cytokine receptor binding	IDA	21817065
GO:0005126	Molecular function	Cytokine receptor binding	IPI	17045821
GO:0005515	Molecular function	Protein binding	IPI	12681488, 17526494, 18677096, 26280537
GO:0042056	Molecular function	Chemoattractant activity	IDA	19602265
GO:0042802	Molecular function	Identical protein binding	IPI	20534506
GO:0050178	Molecular function	Phenylpyruvate tautomerase activity	IDA	16285950, 21817065

Protein Information

Protein Name

Macrophage migration inhibitory factor, L-dopachrome isomerase, L-dopachrome tautomerase, epididymis secretory sperm binding protein, macrophage migration inhibitory factor (glycosylation-inhibiting factor), phenylpyruvate tautomerase

Function

Pro-inflammatory cytokine. Involved in the innate immune response to bacterial pathogens. The expression of MIF at sites of inflammation suggests a role as mediator in regulating the function of macrophages in host defense. Counteracts the anti-inflammatory activity of glucocorticoids. Has phenylpyruvate tautomerase and dopachrome tautomerase activity (in vitro), but the physiological substrate is not known. It is not clear whether the tautomerase activity has any physiological relevance, and whether it is important for cytokine activity

Refseq Proteins

NP_002406.1

UniProt

P14174

PDB

1CA7, 1CGQ, 1GCZ, 1GD0, 1GIF, 1LJT, 1MIF, 1P1G, 2OOH, 2OOW, 2OOZ, 3B9S, 3CE4, 3DJH, 3DJI, 3HOF, 3IJG, 3IJJ, 3JSF, 3JSG, 3JTU, 3L5P, 3L5R, 3L5S, 3L5T, 3L5U, 3L5V, 3SMB, 3SMC, 3U18, 3WNR, 3WNS, 3WNT, 4ETG, 4EUI, 4EVG, 4F2K, 4GRN, 4GRO, 4GRP, 4GRQ, 4GRR, 4GRU, 4GUM, 4K9G, 4OSF, 4OYQ, 4P01, 4P0H, 4PKK, 4PKZ,

Pfam

Pfam Accession	Pfam ID
PF01187	MIF