Gene Information
Gene Symbol
MIRN145, miR-145, miRNA145
Entrez Gene ID
Gene Name
MicroRNA 145
Chromosomal Location
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0010667 Biological process Negative regulation of cardiac muscle cell apoptotic process IDA 23028672
GO:0010668 Biological process Ectodermal cell differentiation IDA 19409607
GO:0016525 Biological process Negative regulation of angiogenesis IDA 25801897
GO:0035195 Biological process Gene silencing by miRNA IDA 15131085, 19409607, 19915607, 20332243, 21351259, 22370644, 23028672, 23390502, 23441135, 24001939, 24065611, 25801897
GO:0035278 Biological process MiRNA mediated inhibition of translation IDA 19360360, 20737575

MicroRNAs in cancer


Associated Diseases

Disease groupDisease NameReferences
Endocrine System Diseases
Esophagus Neoplasm
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
IRS1, p38 MAPK, ERK 
PCOS, chronic oligo-anovulation, hyperandrogenemia, polycystic ovarian morphology, insulin resistance, menstrual dysfunction, hirsutism, acne, and obesity 
Rotterdam consensus 
25 married PCOS women and 25 control women from the Center for Reproduction at the Xijing Hospital  
High concentrations of insulin decreases the miR-145 expression, upregulates IRS1, and promotes cell proliferation. These observations showed that miR-145 is a novel and promising molecular target for improving the dysfunction of GCs in PCOS. 

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