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Gene Symbol |
MIR145 |
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Aliases |
MIRN145, miR-145, miRNA145 |
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Entrez Gene ID |
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Gene Name |
MicroRNA 145 |
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Chromosomal Location |
5q32 |
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HGNC ID |
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Summary |
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
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Gene Ontology (GO)
| GO ID |
Ontology |
Function |
Evidence |
Reference |
| GO:0010667 |
Biological process |
Negative regulation of cardiac muscle cell apoptotic process |
IDA |
23028672 |
| GO:0010668 |
Biological process |
Ectodermal cell differentiation |
IDA |
19409607 |
| GO:0016525 |
Biological process |
Negative regulation of angiogenesis |
IDA |
25801897 |
| GO:0035195 |
Biological process |
Gene silencing by miRNA |
IDA |
15131085, 19409607, 19915607, 20332243, 21351259, 22370644, 23028672, 23390502, 23441135, 24001939, 24065611, 25801897 |
| GO:0035278 |
Biological process |
MiRNA mediated inhibition of translation |
IDA |
19360360, 20737575 |
| GO:0048333 |
Biological process |
Mesodermal cell differentiation |
IDA |
19409607 |
| GO:1904673 |
Biological process |
Negative regulation of somatic stem cell population maintenance |
IDA |
19409607 |
| GO:1904676 |
Biological process |
Negative regulation of somatic stem cell division |
IDA |
19409607 |
| GO:0000993 |
Molecular function |
RNA polymerase II complex binding |
IDA |
25336585 |
| GO:1903231 |
Molecular function |
MRNA binding involved in posttranscriptional gene silencing |
IDA |
15131085, 19360360, 19409607, 19915607, 20332243, 20737575, 21351259, 22370644, 23028672, 23390502, 23441135, 24001939, 25801897 |
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Associated Diseases
| Disease group | Disease Name | References |
| Endocrine System Diseases |
| Glomerulosclerosis |
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| PCOS |
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| Neoplasms |
| Lymphoma |
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| Leukemia |
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| Esophagus Neoplasm |
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| Breast Cancer |
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| Lung Cancer |
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| Renal Disorder |
| Diabetic Nephropathy |
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References |
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| PubMed ID |
Associated gene/s |
Associated condition |
Genetic Mutation |
Diagnostic Criteria |
Association with PCOS |
Ethnicity |
Conclusion |
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IRS1, p38 MAPK, ERK |
PCOS, chronic oligo-anovulation, hyperandrogenemia, polycystic ovarian morphology, insulin resistance, menstrual dysfunction, hirsutism, acne, and obesity |
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Rotterdam consensus |
Related
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25 married PCOS women and 25 control women from the Center for Reproduction at the Xijing Hospital |
High concentrations of insulin decreases the miR-145 expression, upregulates IRS1, and promotes cell proliferation. These observations showed that miR-145 is a novel and promising molecular target for improving the dysfunction of GCs in PCOS. |
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