MIR146A: Polycystic Ovarian Syndrome Database

Gene Information
	Gene Symbol	MIR146A
	Aliases	MIRN146, MIRN146A, miR-146a, miRNA146A
	Entrez Gene ID	406938
	Gene Name	MicroRNA 146a
	Chromosomal Location	5q33.3
	HGNC ID	HGNC:31533
	Summary	microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. Some of the targets of the encoded miRNA are the transcripts for tumor necrosis factor, interleukin 1 receptor-associated kinase 1, interleukin 1-beta, TNF receptor-associated factor 6, and complement factor H. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2015]

SNPs

SNP Id	Upstream Sequence	SNP	Downstream Sequence	Functional Significance	References
rs2910164					29037553

Gene Ontology (GO)

Show/Hide all(33 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001937	Biological process	Negative regulation of endothelial cell proliferation	IDA	23619365
GO:0010628	Biological process	Positive regulation of gene expression	IDA	27121396, 29384235
GO:0010629	Biological process	Negative regulation of gene expression	IDA	29384235
GO:0016525	Biological process	Negative regulation of angiogenesis	IMP	23619365
GO:0032715	Biological process	Negative regulation of interleukin-6 production	IDA	28433754
GO:0034121	Biological process	Regulation of toll-like receptor signaling pathway	IDA	16885212
GO:0035195	Biological process	Gene silencing by miRNA	IDA	16885212, 20181935, 23619365, 24863965, 25515214, 27121396, 28727754
GO:0035195	Biological process	Gene silencing by miRNA	IMP	18801740, 20937840
GO:0038061	Biological process	NIK/NF-kappaB signaling	IMP	20937840
GO:0042532	Biological process	Negative regulation of tyrosine phosphorylation of STAT protein	IDA	28433754
GO:0045666	Biological process	Positive regulation of neuron differentiation	IC	29384235
GO:0045743	Biological process	Positive regulation of fibroblast growth factor receptor signaling pathway	IDA	27121396
GO:0060253	Biological process	Negative regulation of glial cell proliferation	IDA	29384235
GO:0070498	Biological process	Interleukin-1-mediated signaling pathway	IMP	20937840
GO:0071222	Biological process	Cellular response to lipopolysaccharide	IDA	16885212
GO:0071333	Biological process	Cellular response to glucose stimulus	IDA	28433754
GO:0071345	Biological process	Cellular response to cytokine stimulus	IDA	25515214
GO:0071456	Biological process	Cellular response to hypoxia	IMP	18801740
GO:0090050	Biological process	Positive regulation of cell migration involved in sprouting angiogenesis	IDA	27121396
GO:0090050	Biological process	Positive regulation of cell migration involved in sprouting angiogenesis	IMP	24863965
GO:0090051	Biological process	Negative regulation of cell migration involved in sprouting angiogenesis	IMP	28727754
GO:0098586	Biological process	Cellular response to virus	IDA	20181935
GO:1901223	Biological process	Negative regulation of NIK/NF-kappaB signaling	IDA	25515214
GO:1902511	Biological process	Negative regulation of apoptotic DNA fragmentation	IDA	28433754
GO:1903589	Biological process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA	27121396
GO:1904046	Biological process	Negative regulation of vascular endothelial growth factor production	IDA	28433754
GO:1904646	Biological process	Cellular response to amyloid-beta	IMP	20937840
GO:1904995	Biological process	Negative regulation of leukocyte adhesion to vascular endothelial cell	IDA	25515214
GO:2000736	Biological process	Regulation of stem cell differentiation	IDA	29384235
GO:0005615	Cellular component	Extracellular space	HDA	18766170
GO:0005615	Cellular component	Extracellular space	IDA	26646931
GO:0070062	Cellular component	Extracellular exosome	IDA	23619365
GO:1903231	Molecular function	MRNA binding involved in posttranscriptional gene silencing	IDA	16885212, 20181935, 23619365, 25515214, 27121396, 28727754