MIR155: Polycystic Ovarian Syndrome Database

Gene Information
	Gene Symbol	MIR155
	Aliases	MIRN155, miRNA155, mir-155
	Entrez Gene ID	406947
	Gene Name	MicroRNA 155
	Chromosomal Location	21q21.3
	HGNC ID	HGNC:31542
	Summary	microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology (GO)

Show/Hide all(53 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001818	Biological process	Negative regulation of cytokine production	IDA	24885259
GO:0010628	Biological process	Positive regulation of gene expression	IDA	24885259
GO:0010628	Biological process	Positive regulation of gene expression	IMP	30031401
GO:0010629	Biological process	Negative regulation of gene expression	IDA	19193853
GO:0010629	Biological process	Negative regulation of gene expression	IMP	19193853, 21030878, 27731397
GO:0010823	Biological process	Negative regulation of mitochondrion organization	IDA	25869329
GO:0010989	Biological process	Negative regulation of low-density lipoprotein particle clearance	IDA	21030878
GO:0032088	Biological process	Negative regulation of NF-kappaB transcription factor activity	IMP	21030878
GO:0032496	Biological process	Response to lipopolysaccharide	IDA	19193853
GO:0032717	Biological process	Negative regulation of interleukin-8 production	IDA	20219467
GO:0035195	Biological process	Gene silencing by miRNA	IDA	20550618, 21310411, 21355095, 22387553, 24804980, 25219837, 25850724, 25869329, 25910754, 26589288, 27185878, 27731397, 28408180
GO:0035195	Biological process	Gene silencing by miRNA	IGI	27185878
GO:0035195	Biological process	Gene silencing by miRNA	IMP	19136465, 19193853, 21030878
GO:0035278	Biological process	MiRNA mediated inhibition of translation	IDA	20219467
GO:0042104	Biological process	Positive regulation of activated T cell proliferation	IGI	22387553
GO:0042632	Biological process	Cholesterol homeostasis	IMP	21030878
GO:0042742	Biological process	Defense response to bacterium	IDA	20219467
GO:0043537	Biological process	Negative regulation of blood vessel endothelial cell migration	IDA	21310411
GO:0044828	Biological process	Negative regulation by host of viral genome replication	IDA	24885259
GO:0045397	Biological process	Negative regulation of interleukin-23 biosynthetic process	IDA	19193853
GO:0045590	Biological process	Negative regulation of regulatory T cell differentiation	IGI	22387553
GO:0045824	Biological process	Negative regulation of innate immune response	IDA	24885259
GO:0050724	Biological process	Negative regulation of interleukin-1 beta biosynthetic process	IDA	19193853
GO:0050728	Biological process	Negative regulation of inflammatory response	IDA	21310411
GO:0050728	Biological process	Negative regulation of inflammatory response	IMP	21030878
GO:0051607	Biological process	Defense response to virus	IDA	24885259
GO:0060354	Biological process	Negative regulation of cell adhesion molecule production	IDA	21310411
GO:0060545	Biological process	Positive regulation of necroptotic process	IDA	21355095
GO:0060546	Biological process	Negative regulation of necroptotic process	IDA	25910754
GO:0060547	Biological process	Negative regulation of necrotic cell death	IDA	20550618
GO:0061044	Biological process	Negative regulation of vascular wound healing	IDA	21310411
GO:0070498	Biological process	Interleukin-1-mediated signaling pathway	IMP	30031401
GO:0071404	Biological process	Cellular response to low-density lipoprotein particle stimulus	IMP	21030878
GO:0071644	Biological process	Negative regulation of chemokine (C-C motif) ligand 4 production	IDA	19193853
GO:0090051	Biological process	Negative regulation of cell migration involved in sprouting angiogenesis	IDA	28408180
GO:0090298	Biological process	Negative regulation of mitochondrial DNA replication	IDA	25869329
GO:0097028	Biological process	Dendritic cell differentiation	IDA	21355095
GO:1900016	Biological process	Negative regulation of cytokine production involved in inflammatory response	IDA	20219467
GO:1900181	Biological process	Negative regulation of protein localization to nucleus	IMP	21030878
GO:1902396	Biological process	Protein localization to bicellular tight junction	IDA	28408180
GO:1903206	Biological process	Negative regulation of hydrogen peroxide-induced cell death	IDA	20550618
GO:1903347	Biological process	Negative regulation of bicellular tight junction assembly	IDA	28408180
GO:1903588	Biological process	Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA	25850724, 28408180
GO:1903672	Biological process	Positive regulation of sprouting angiogenesis	IDA	27731397
GO:1903979	Biological process	Negative regulation of microglial cell activation	IDA	24885259
GO:1904995	Biological process	Negative regulation of leukocyte adhesion to vascular endothelial cell	IDA	21310411
GO:2000339	Biological process	Negative regulation of chemokine (C-X-C motif) ligand 1 production	IDA	19193853
GO:2000670	Biological process	Positive regulation of dendritic cell apoptotic process	IDA	21355095
GO:2000725	Biological process	Regulation of cardiac muscle cell differentiation	IDA	20550618
GO:2001184	Biological process	Positive regulation of interleukin-12 secretion	IDA	21355095
GO:0005615	Cellular component	Extracellular space	HDA	26646931
GO:0070062	Cellular component	Extracellular exosome	IDA	28408180
GO:1903231	Molecular function	MRNA binding involved in posttranscriptional gene silencing	IDA	19193853, 20219467, 20550618, 21310411, 21355095, 25219837, 25869329, 25910754, 26589288, 27185878, 27731397, 28408180