MIR16-2: Polycystic Ovarian Syndrome Database

Gene Information
	Gene Symbol	MIR16-2
	Aliases	MIRN16-2, mir-16-2, mir-16-3
	Entrez Gene ID	406951
	Gene Name	MicroRNA 16-2
	Chromosomal Location	3q25.33
	HGNC ID	HGNC:31546
	Summary	microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology (GO)

Show/Hide all(28 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001937	Biological process	Negative regulation of endothelial cell proliferation	IDA	21885851
GO:0008285	Biological process	Negative regulation of cell proliferation	IGI	22139073
GO:0016525	Biological process	Negative regulation of angiogenesis	IDA	21885851, 23233752
GO:0032088	Biological process	Negative regulation of NF-kappaB transcription factor activity	IDA	30365148
GO:0035195	Biological process	Gene silencing by miRNA	IDA	15131085, 16166262, 18449891, 19823025, 21532615, 21885851, 22139073, 23487264, 25033200, 25261849, 25594541, 25743273, 27343180, 27748453
GO:0035278	Biological process	MiRNA mediated inhibition of translation	IDA	23233752
GO:0035278	Biological process	MiRNA mediated inhibition of translation	IGI	25403480
GO:0040037	Biological process	Negative regulation of fibroblast growth factor receptor signaling pathway	IDA	21885851
GO:0043065	Biological process	Positive regulation of apoptotic process	IDA	25261849
GO:0043124	Biological process	Negative regulation of I-kappaB kinase/NF-kappaB signaling	IDA	23487264
GO:0045727	Biological process	Positive regulation of translation	IGI	25403480
GO:0050728	Biological process	Negative regulation of inflammatory response	IDA	30365148
GO:0071333	Biological process	Cellular response to glucose stimulus	IDA	30365148
GO:0090051	Biological process	Negative regulation of cell migration involved in sprouting angiogenesis	IDA	27748453
GO:0110081	Biological process	Negative regulation of placenta blood vessel development	IDA	27748453
GO:1900747	Biological process	Negative regulation of vascular endothelial growth factor signaling pathway	IDA	21885851
GO:1903588	Biological process	Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA	21885851, 27748453
GO:1904848	Biological process	Negative regulation of cell chemotaxis to fibroblast growth factor	IDA	23233752
GO:1904858	Biological process	Negative regulation of endothelial cell chemotaxis to vascular endothelial growth factor	IDA	21885851
GO:2000134	Biological process	Negative regulation of G1/S transition of mitotic cell cycle	IDA	25261849
GO:2000134	Biological process	Negative regulation of G1/S transition of mitotic cell cycle	IGI	21454377
GO:2000545	Biological process	Negative regulation of endothelial cell chemotaxis to fibroblast growth factor	IDA	21885851
GO:2001244	Biological process	Positive regulation of intrinsic apoptotic signaling pathway	IGI	16166262
GO:0005615	Cellular component	Extracellular space	HDA	18766170, 26646931
GO:0005615	Cellular component	Extracellular space	IDA	20159880
GO:0070062	Cellular component	Extracellular exosome	IDA	23233752, 28159509
GO:0000993	Molecular function	RNA polymerase II complex binding	IDA	25336585
GO:1903231	Molecular function	MRNA binding involved in posttranscriptional gene silencing	IDA	15131085, 16166262, 18449891, 19823025, 21532615, 21885851, 22139073, 23233752, 25033200, 25261849, 25594541, 25743273, 27343180, 27748453