Gene Information
Gene Symbol
MIRN16-2, mir-16-2, mir-16-3
Entrez Gene ID
Gene Name
MicroRNA 16-2
Chromosomal Location
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0001937 Biological process Negative regulation of endothelial cell proliferation IDA 21885851
GO:0008285 Biological process Negative regulation of cell proliferation IGI 22139073
GO:0016525 Biological process Negative regulation of angiogenesis IDA 21885851, 23233752
GO:0032088 Biological process Negative regulation of NF-kappaB transcription factor activity IDA 30365148
GO:0035195 Biological process Gene silencing by miRNA IDA 15131085, 16166262, 18449891, 19823025, 21532615, 21885851, 22139073, 23487264, 25033200, 25261849, 25594541, 25743273, 27343180, 27748453

MicroRNAs in cancer


Associated Diseases

Disease groupDisease NameReferences
Endocrine System Diseases
Polycythemia vera
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
PCOS, amenorrhea, abnormal folliculogenesis, chronic anovulation, hyperandrogenemia, infertility, insulin resistance, obesity, dyslipidemia, hypertension, pancreatic ?-cell dysfunction, increasing the risk of type 2 diabetes mellitus (T2DM), and cardiovas 
Rotterdam 2003 criteria 
19 PCOS women and 19 control women 
miR-16 promoted ovarian GCs proliferation and inhibited apoptosis through directly targeting PDCD4 in PCOS, contributing to a better understanding of the molecular mechanism of GCs dysregulation and providing a promising target in PCOS. 

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