Gene Information
Gene Symbol
C13orf25, MIR17HG, MIR19B, MIRH1, MIRHG1, MIRN19B1, miR-19b-1, miRNA19B1
Entrez Gene ID
Gene Name
MicroRNA 19b-1
Chromosomal Location
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
RefSeq DNA
RefSeq mRNA

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0010629 Biological process Negative regulation of gene expression IDA 25765596
GO:0010972 Biological process Negative regulation of G2/M transition of mitotic cell cycle IDA 22197821
GO:0035195 Biological process Gene silencing by miRNA IDA 18728182, 22197821, 23271053, 24998411, 25084135
GO:0035278 Biological process MiRNA mediated inhibition of translation IDA 21796614
GO:0042531 Biological process Positive regulation of tyrosine phosphorylation of STAT protein IMP 18728182

MicroRNAs in cancer


Associated Diseases

Disease groupDisease NameReferences
Blood Disorders
Cardiovascular Diseases
Angina pectoris
Coronary heart disease
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Extrahepatic biliary duct atresia
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
IGF-1, CDK1, cyclin D1 
PCOS, hyperandrogenemia, chronic anovulation, menstrual disorders, subfertility, acne vulgaris, alopecia, seborrhea, obesity, hirsutism, acanthosis, insulin resistance, hypertension, type 2 diabetes mellitus, oxidative stress, dyslipidemia, cardiovascular 
Rotterdam European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine criteria (2003) 
18 PCOS women and 10 control women  
Overexpression of miR?19b may be a potential therapeutic approach for PCOS 

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