MIR222: Polycystic Ovarian Syndrome Database

Gene Information
	Gene Symbol	MIR222
	Aliases	MIRN222, miRNA222, mir-222
	Entrez Gene ID	407007
	Gene Name	MicroRNA 222
	Chromosomal Location	Xp11.3
	HGNC ID	HGNC:31602
	Summary	microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

SNPs

SNP Id	Upstream Sequence	SNP	Downstream Sequence	Functional Significance	References
rs2858060					29037553

Gene Ontology (GO)

Show/Hide all(24 )

GO ID	Ontology	Function	Evidence	Reference
GO:0010634	Biological process	Positive regulation of epithelial cell migration	IGI	21673316
GO:0010718	Biological process	Positive regulation of epithelial to mesenchymal transition	IGI	21673316
GO:0016525	Biological process	Negative regulation of angiogenesis	IDA	20489169
GO:0035195	Biological process	Gene silencing by miRNA	IDA	16330772, 18413744, 19153141, 19487542, 19962668, 20299489, 20388878, 20489169, 21711453, 21761362, 22321642, 23587485, 23770851, 23969726, 24147153, 24736554, 29230236
GO:0035195	Biological process	Gene silencing by miRNA	IGI	21310411, 21673316, 22294051
GO:0035195	Biological process	Gene silencing by miRNA	IMP	18246122, 20103675, 20813046, 26045994
GO:0035278	Biological process	MiRNA mediated inhibition of translation	IDA	19962668
GO:0043066	Biological process	Negative regulation of apoptotic process	IDA	20813046
GO:0045648	Biological process	Positive regulation of erythrocyte differentiation	IDA	16330772
GO:0050728	Biological process	Negative regulation of inflammatory response	IGI	21310411
GO:0051897	Biological process	Positive regulation of protein kinase B signaling	IDA	19962668
GO:0060354	Biological process	Negative regulation of cell adhesion molecule production	IGI	21310411
GO:0070374	Biological process	Positive regulation of ERK1 and ERK2 cascade	IDA	19962668
GO:0090263	Biological process	Positive regulation of canonical Wnt signaling pathway	IDA	23587485
GO:1900087	Biological process	Positive regulation of G1/S transition of mitotic cell cycle	IDA	18413744
GO:1902034	Biological process	Negative regulation of hematopoietic stem cell proliferation	IDA	16330772
GO:1903122	Biological process	Negative regulation of TRAIL-activated apoptotic signaling pathway	IDA	19962668
GO:1903122	Biological process	Negative regulation of TRAIL-activated apoptotic signaling pathway	IMP	18246122
GO:1903588	Biological process	Negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IDA	20489169
GO:1904995	Biological process	Negative regulation of leukocyte adhesion to vascular endothelial cell	IGI	21310411
GO:0005615	Cellular component	Extracellular space	HDA	18766170, 26646931
GO:1903231	Molecular function	MRNA binding involved in posttranscriptional gene silencing	IDA	16330772, 18413744, 19153141, 19487542, 19962668, 20299489, 20388878, 20489169, 21711453, 21761362, 22321642, 23587485, 23770851, 23969726, 24147153, 24736554, 29230236
GO:1903231	Molecular function	MRNA binding involved in posttranscriptional gene silencing	IGI	21310411, 21673316, 22294051
GO:1903231	Molecular function	MRNA binding involved in posttranscriptional gene silencing	IMP	20103675, 20813046, 26045994