MIR223

Gene Information
 
Gene Symbol
MIR223
 
Aliases
MIRN223, miRNA223, mir-223
 
Entrez Gene ID
 
Gene Name
MicroRNA 223
 
Chromosomal Location
Xq12
 
HGNC ID
 
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0010628 Biological process Positive regulation of gene expression IDA 20080987
GO:0034260 Biological process Negative regulation of GTPase activity IDA 27121304
GO:0035195 Biological process Gene silencing by miRNA IDA 27121304
GO:0046326 Biological process Positive regulation of glucose import IDA 20080987
GO:1901342 Biological process Regulation of vasculature development IDA 27121304
Pathways
 
KEGG
 
 

MicroRNAs in cancer

  

Associated Diseases

Disease groupDisease NameReferences
Blood Disorders
Hematopoietic Disease
Blood Coagulation Disorders
Myelodysplastic Syndrome
Kawasaki disease
Cardiovascular Diseases
Acute Coronary Syndrome
References
 
 
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
IRS,P13K,AKT, GLUT4, MIR93, MIR133, PTEN 
PCOS, insulin resistance, hyperinsulinemia, type 2 diabetes mellitus (T2DM), cardiovascular disease  
 
 National Institute of Health (1990) criteiria 
Related 
21 PCOS women and 20 control women 
 Overexpression of miR-93 resulted in downregulation of GLUT4 gene expression in adipocytes through direct targeting of the GLUT4 3'UTR, while inhibition of miR-93 activity led to increased GLUT4 expression. These results point to a novel mechanism for regulating insulin-stimulated glucose uptake via miR-93 and demonstrate upregulated miR-93 expression in all PCOS, and in non-PCOS women with IR, possibly accounting for the IR of the syndrome. In contrast, miR-133 and miR-223 may have a different, although yet to be defined, role in the IR of PCOS. 
TNF-?, GLUT4 
PCOS, insulin resistance, compensatory hyperinsulinemia, type 2 diabetes mellitus (T2DM), metabolic syndrome 
 
 National Institute of Health (1990) criteiria 
Related 
18 PCOS women and 15 control women  
 miR-223 is an IR-related miRNA that may serve as a potential therapeutic target for the treatment of IR-related disorders. 
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