MIR23A: Polycystic Ovarian Syndrome Database

Gene Information
	Gene Symbol	MIR23A
	Aliases	MIRN23A, hsa-mir-23a, miRNA23A, mir-23a
	Entrez Gene ID	407010
	Gene Name	MicroRNA 23a
	Chromosomal Location	19p13.12
	HGNC ID	HGNC:31605
	Summary	microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology (GO)

Show/Hide all(12 )

GO ID	Ontology	Function	Evidence	Reference
GO:0035195	Biological process	Gene silencing by miRNA	IDA	15131085, 27741223
GO:0035195	Biological process	Gene silencing by miRNA	IGI	21536891
GO:0035924	Biological process	Cellular response to vascular endothelial growth factor stimulus	IGI	21536891
GO:0043116	Biological process	Negative regulation of vascular permeability	IDA	27741223
GO:0070374	Biological process	Positive regulation of ERK1 and ERK2 cascade	IGI	21536891
GO:0090050	Biological process	Positive regulation of cell migration involved in sprouting angiogenesis	IGI	21536891
GO:1903589	Biological process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI	21536891
GO:1903670	Biological process	Regulation of sprouting angiogenesis	IDA	27741223
GO:0005615	Cellular component	Extracellular space	HDA	18766170, 26646931
GO:0070062	Cellular component	Extracellular exosome	IDA	28159509
GO:1903231	Molecular function	MRNA binding involved in posttranscriptional gene silencing	IDA	15131085, 27741223
GO:1903231	Molecular function	MRNA binding involved in posttranscriptional gene silencing	IGI	21536891