Gene Information
Gene Symbol
MIRN23A, hsa-mir-23a, miRNA23A, mir-23a
Entrez Gene ID
Gene Name
MicroRNA 23a
Chromosomal Location
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0035195 Biological process Gene silencing by miRNA IDA 15131085, 27741223
GO:0035195 Biological process Gene silencing by miRNA IGI 21536891
GO:0035924 Biological process Cellular response to vascular endothelial growth factor stimulus IGI 21536891
GO:0043116 Biological process Negative regulation of vascular permeability IDA 27741223
GO:0070374 Biological process Positive regulation of ERK1 and ERK2 cascade IGI 21536891

MicroRNAs in cancer


Associated Diseases

Disease groupDisease NameReferences
Digestive System Diseases
Liver Diseases
Endocrine System Diseases
Psychiatric/Brain disorders
Autistic Disorder
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
PCOS, chronic anovulation, hyperandrogenism, infertility, obesity, insulin resistance, diabetes 
Rotterdam consensus criteria 
18 PCOS women and 30 control women  
Both reduced levels and discordance between the expressions of miR-23a/b were observed in the women with PCOS and miR-23a/b were affected from testosterone and BMI, reversely. Therefore, miR-23a alteration in contrast with miR-23b is a better indicator for evaluation of PCOS than the miR-23b 

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