MIR23B: Polycystic Ovarian Syndrome Database

Gene Information
	Gene Symbol	MIR23B
	Aliases	MIRN23B, hsa-mir-23b, miRNA23B, mir-23b
	Entrez Gene ID	407011
	Gene Name	MicroRNA 23b
	Chromosomal Location	9q22.32
	HGNC ID	HGNC:31606
	Summary	microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology (GO)

Show/Hide all(14 )

GO ID	Ontology	Function	Evidence	Reference
GO:0010628	Biological process	Positive regulation of gene expression	IGI	28111633
GO:0010629	Biological process	Negative regulation of gene expression	IDA	28111633
GO:0035195	Biological process	Gene silencing by miRNA	IDA	27741223, 28111633
GO:0035195	Biological process	Gene silencing by miRNA	IGI	21536891
GO:0035924	Biological process	Cellular response to vascular endothelial growth factor stimulus	IGI	21536891
GO:0043117	Biological process	Positive regulation of vascular permeability	IDA	27741223
GO:0060045	Biological process	Positive regulation of cardiac muscle cell proliferation	IDA	28111633
GO:0070374	Biological process	Positive regulation of ERK1 and ERK2 cascade	IGI	21536891
GO:0090050	Biological process	Positive regulation of cell migration involved in sprouting angiogenesis	IGI	21536891
GO:1903589	Biological process	Positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI	21536891
GO:1903671	Biological process	Negative regulation of sprouting angiogenesis	IDA	27741223
GO:0005615	Cellular component	Extracellular space	HDA	26646931
GO:1903231	Molecular function	MRNA binding involved in posttranscriptional gene silencing	IDA	27741223, 28111633
GO:1903231	Molecular function	MRNA binding involved in posttranscriptional gene silencing	IGI	21536891