MIR320A

Gene Information
 
Gene Symbol
MIR320A
 
Aliases
MIRN320, MIRN320A, hsa-mir-320a, mir-320a
 
Entrez Gene ID
 
Gene Name
MicroRNA 320a
 
Chromosomal Location
8p21.3
 
HGNC ID
 
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0035195 Biological process Gene silencing by miRNA IDA 26395742
GO:0005615 Cellular component Extracellular space IDA 26646931
GO:1903231 Molecular function MRNA binding involved in posttranscriptional gene silencing IDA 26395742

Associated Diseases

Disease groupDisease NameReferences
Digestive System Diseases
Liver Diseases
Hepatitis
Endocrine System Diseases
PCOS
References
 
 
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
 
PCOS, anovulatory infertility, compensatory hyperinsulinemia, type 2 diabetes, insulin resistance  
 
 Rotterdam European Society of Human Reproduction (revised) and Embryology/American Society for Reproductive Medicine criteria (2003) 
Related 
16 PCOS women  
 Expression of miR-320a was upregulated in PCOS tissues compared with normal tissues, and miR-320a expression in PCOS tissues and KGN granulosa cells was demonstrated to be insulin related. Tissues with higher insulin levels, or cells treated with higher insulin, revealed higher miR?320a expression than normal controls. Furthermore, dual?Luciferase reporter assay revealed PCGF1 was a target of miR-320a. Inhibition of miR-320a through ASO-miR-320a inhibited insulin-induced increases in cell viability and cell colony formation, and reversed insulin-induced reductions in cell apoptosis. These data demonstrated that miR-320a may serve as a biomarker of PCOS, and that insulin-induced KGN cell proliferation was related to miR-320a through targeting PCGF1. 
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