Gene Information
Gene Symbol
MIR323, MIRN323, hsa-mir-323, hsa-mir-323a, mir-323a
Entrez Gene ID
Gene Name
MicroRNA 323a
Chromosomal Location
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0005615 Cellular component Extracellular space HDA 26646931

Associated Diseases

Disease groupDisease NameReferences
Endocrine System Diseases
Thyroid Cancer
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
IGF-1, AR, AMHR-II, CYP19A, EGFR, GATA-4, mir-483-5p, mir-486-5p, miR-93, miR-21, miR-323-3p, miR-27a-3p 
PCOS, Abnormal folliculogenesis, menstrual irregularity, failure in follicle maturation, anovulation, infertility,  
Rotterdam European Society of Human Reproduction and Embryology/American Society for Reproductive Medicine Criteria (2004) 
20 PCOS and 20 non-PCOS patients 
miR-323-3p is a novel and promising molecular target for the improvement of the dysfunction of CCs in PCOS. 

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