MIR429

Gene Information
 
Gene Symbol
MIR429
 
Aliases
MIRN429, hsa-mir-429, mir-429
 
Entrez Gene ID
 
Gene Name
MicroRNA 429
 
Chromosomal Location
1p36.33
 
HGNC ID
 
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0035195 Biological process Gene silencing by miRNA IDA 25152461
GO:1903231 Molecular function MRNA binding involved in posttranscriptional gene silencing IDA 25152461

Associated Diseases

Disease groupDisease NameReferences
Digestive System Diseases
Pancreatitis
Endocrine System Diseases
PCOS
Neoplasms
Breast Cancer
References
 
 
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
MIR200B, ZEB1, ZEB2 
PCOS 
 
 Rotterdam revised criteria 
Related 
Group 1: 7 Normal Cycling Women, Group 2: 15 Normal Cycling Women undergoing IVF treatment; Group 3: 18 Anovulatory PCOS women 
 Our findings suggest an involvement of miRNA-200b and miRNA-429 in the pituitary regulation of human ovulation. Although it is unclear whether this altered miRNA expression profile is a cause or a result of anovulation, the levels of these molecules in the serum of anovulatory women may serve as serum biomarkers for the ovulation process 
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