MIR574

Gene Information
 
Gene Symbol
MIR574
 
Aliases
MIR574-3p, MIRN574, hsa-mir-574, mir-574
 
Entrez Gene ID
 
Gene Name
MicroRNA 574
 
Chromosomal Location
4p14
 
HGNC ID
 
Summary
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0005615 Cellular component Extracellular space HDA 26646931

Associated Diseases

Disease groupDisease NameReferences
Digestive System Diseases
Hepatitis
Liver Diseases
Endocrine System Diseases
PCOS
Psychiatric/Brain disorders
Obstructive Sleep Apnea
References
 
 
PubMed ID Associated gene/s Associated condition Genetic Mutation Diagnostic Criteria Association with PCOS Ethnicity Conclusion
MIR24, MIR29A, MIR151, MIR518F, MIR132-3P, MIR193B-3P, MIR320A, FBN1, COL3A1, INRS, ITGB1, MEF2A, TGBF2, MIR18B, MIR9, MIR32, MIR34C, MIR135A, hsa-MIR302C-3P, hsa-MIR-1243, hsa- MIR1274B, hsa-MIR-151A-3P, hsa-MIR-627-5P, hsa-MIR-155-5P, hsa-MIR518F-3P, h 
PCOS, menstrual disturbances with oligo- and anovulation, hyperandrogenism in terms of hirsutism, acne, alopecia,elevated T concentration, obesity, insulin resistance, low-grade inflammation, cardiovascular diseases. 
 
 Rotterdam 2003 consensus criteria 
Related 
49 PCOS women and 21 control women  
 Our study provides evidence that the miRNA expression profile in follicular fluid is altered in PCOS and indicates that specific follicular fluid miRNAs are associated with phenotypical traits of PCOS. An altered miRNA profile holds potentials for new methods of PCOS patient stratification and may contribute to and in part explain the heterogeneous nature found within PCOS women. 
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