Gene Information
Gene Symbol
LET7I, MIRNLET7I, hsa-let-7i, let-7i
Entrez Gene ID
Gene Name
MicroRNA let-7i
Chromosomal Location
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0010629 Biological process Negative regulation of gene expression IDA 28844675
GO:0035195 Biological process Gene silencing by miRNA IDA 27784773, 28844675
GO:0045899 Biological process Positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IDA 25336585
GO:0045944 Biological process Positive regulation of transcription by RNA polymerase II IMP 25336585
GO:0005615 Cellular component Extracellular space HDA 26646931

MicroRNAs in cancer


Associated Diseases

Disease groupDisease NameReferences
Digestive System Diseases
Liver Diseases
Endocrine System Diseases
Reproductive disorders

Circulating microRNAs in patients with polycystic ovary syndrome.

Ding Cai-Fei, Chen Wang-Qiang, Zhu Yu-Tian, Bo Ya-Li, Hu Hui-Min, Zheng Ruo-Heng
Reproductive Department, Integrated Chinese and Western Medicine Hospital of Zhejiang Province , Hangzhou , P. R. China.
Hum Fertil (Camb). 2015 Mar;18(1):22-9. doi: 10.3109/14647273.2014.956811. Epub

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