MMP8: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

MMP8

Aliases

CLG1, HNC, MMP-8, PMNL-CL

Entrez Gene ID

4317

Gene Name

Matrix metallopeptidase 8

Chromosomal Location

11q22.2

HGNC ID

HGNC:7175

Summary

This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]

RefSeq DNA

NG_012101.1

RefSeq mRNA

NM_002424.3, NM_001304441.2, NM_001304442.2

e!Ensembl

Gene	ENSG00000118113
Transcript	ENST00000236826, ENST00000528662, ENST00000438475, ENST00000533258, ENST00000531168, ENST00000532799
Protein	ENSP00000236826, ENSP00000431431, ENSP00000401004, ENSP00000437173, ENSP00000433812, ENSP00000431938

Gene Ontology (GO)

Show/Hide all(26 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006508	Biological process	Proteolysis	IDA	2164002
GO:0010628	Biological process	Positive regulation of gene expression	ISS	25049354
GO:0010629	Biological process	Negative regulation of gene expression	ISS	25049354
GO:0030198	Biological process	Extracellular matrix organization	IBA	21873635
GO:0030574	Biological process	Collagen catabolic process	IBA	21873635
GO:0032693	Biological process	Negative regulation of interleukin-10 production	ISS	25049354
GO:0032755	Biological process	Positive regulation of interleukin-6 production	ISS	25049354
GO:0035987	Biological process	Endodermal cell differentiation	IEP	23154389
GO:0043388	Biological process	Positive regulation of DNA binding	ISS	25049354
GO:0043410	Biological process	Positive regulation of MAPK cascade	ISS	25049354
GO:0045429	Biological process	Positive regulation of nitric oxide biosynthetic process	ISS	25049354
GO:0046330	Biological process	Positive regulation of JNK cascade	ISS	25049354
GO:0150077	Biological process	Regulation of neuroinflammatory response	TAS	25049354
GO:0150078	Biological process	Positive regulation of neuroinflammatory response	ISS	25049354
GO:1901224	Biological process	Positive regulation of NIK/NF-kappaB signaling	ISS	25049354
GO:1903428	Biological process	Positive regulation of reactive oxygen species biosynthetic process	ISS	25049354
GO:1903978	Biological process	Regulation of microglial cell activation	TAS	25049354
GO:1903980	Biological process	Positive regulation of microglial cell activation	ISS	25049354
GO:1904469	Biological process	Positive regulation of tumor necrosis factor secretion	ISS	25049354
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IDA	2164002, 24784232
GO:0062023	Cellular component	Collagen-containing extracellular matrix	HDA	28344315
GO:0004175	Molecular function	Endopeptidase activity	IMP	25049354
GO:0004222	Molecular function	Metalloendopeptidase activity	IBA	21873635
GO:0004252	Molecular function	Serine-type endopeptidase activity	IDA	2164002, 16192646
GO:0008270	Molecular function	Zinc ion binding	TAS	2164002

Protein Information

Protein Name

Neutrophil collagenase, PMN leukocyte collagenase, PMNL collagenase, collagenase 2, matrix metalloproteinase 8 (neutrophil collagenase), matrix metalloproteinase-8

Function

Can degrade fibrillar type I, II, and III collagens

Refseq Proteins

NP_002415.1, NP_001291370.1, NP_001291371.1

UniProt

P22894

PDB

1A85, 1A86, 1BZS, 1I73, 1I76, 1JAN, 1JAO, 1JAP, 1JAQ, 1JH1, 1JJ9, 1KBC, 1MMB, 1MNC, 1ZP5, 1ZS0, 1ZVX, 2OY2, 2OY4, 3DNG, 3DPE, 3DPF, 3TT4, 4QKZ, 5H8X

Pfam

Pfam Accession	Pfam ID
PF00045	Hemopexin
PF00413	Peptidase_M10
PF01471	PG_binding_1