MTCH2: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

MTCH2

Aliases

HSPC032, MIMP, SLC25A50

Entrez Gene ID

23788

Gene Name

Mitochondrial carrier 2

Chromosomal Location

11p11.2

HGNC ID

HGNC:17587

Summary

This gene encodes a member of the SLC25 family of nuclear-encoded transporters that are localized in the inner mitochondrial membrane. Members of this superfamily are involved in many metabolic pathways and cell functions. Genome-wide association studies in human have identified single-nucleotide polymorphisms in several loci associated with obesity. This gene is one such locus, which is highly expressed in white adipose tissue and adipocytes, and thought to play a regulatory role in adipocyte differentiation and biology. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target that can produce two isoforms from the same mRNA by use of alternative in-frame translation termination codons. [provided by RefSeq, Dec 2017]

e!Ensembl

Gene	ENSG00000109919, ENSG00000285121
Transcript	ENST00000302503, ENST00000530428, ENST00000643223, ENST00000642838
Protein	ENSP00000303222, ENSP00000432043, ENSP00000495027, ENSP00000494421

Gene Ontology (GO)

Show/Hide all(5 )

GO ID	Ontology	Function	Evidence	Reference
GO:0043065	Biological process	Positive regulation of apoptotic process	IBA	21873635
GO:0070585	Biological process	Protein localization to mitochondrion	IMP	23744079
GO:0005634	Cellular component	Nucleus	HDA	21630459
GO:0005739	Cellular component	Mitochondrion	IBA	21873635
GO:0016020	Cellular component	Membrane	HDA	19946888

Protein Information

Protein Name

Mitochondrial carrier homolog 2, 2310034D24Rik, met-induced mitochondrial protein, solute carrier family 25, member 50

Function

The substrate transported is not yet known. Induces mitochondrial depolarization

UniProt

Q9Y6C9

Pfam

Pfam Accession	Pfam ID
PF00153	Mito_carr