MTNR1A: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

MTNR1A

Aliases

MEL-1A-R, MT1

Entrez Gene ID

4543

Gene Name

Melatonin receptor 1A

Chromosomal Location

4q35.2

HGNC ID

HGNC:7463

Summary

This gene encodes one of two high affinity forms of a receptor for melatonin, the primary hormone secreted by the pineal gland. This receptor is a G-protein coupled, 7-transmembrane receptor that is responsible for melatonin effects on mammalian circadian rhythm and reproductive alterations affected by day length. The receptor is an integral membrane protein that is readily detectable and localized to two specific regions of the brain. The hypothalamic suprachiasmatic nucleus appears to be involved in circadian rhythm while the hypophysial pars tuberalis may be responsible for the reproductive effects of melatonin. [provided by RefSeq, Jul 2008]

e!Ensembl

Gene	ENSG00000168412
Transcript	ENST00000307161
Protein	ENSP00000302811

Gene Ontology (GO)

Show/Hide all(12 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007187	Biological process	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	TAS	9645677
GO:0007193	Biological process	Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA	10531408
GO:0007617	Biological process	Mating behavior	TAS	7946354
GO:0007623	Biological process	Circadian rhythm	IBA	21873635
GO:0005886	Cellular component	Plasma membrane	IBA	21873635
GO:0005887	Cellular component	Integral component of plasma membrane	IDA	10531408
GO:0043235	Cellular component	Receptor complex	IDA	10531408
GO:0004930	Molecular function	G protein-coupled receptor activity	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	17215244, 20859254, 26514267, 28298427
GO:0008502	Molecular function	Melatonin receptor activity	IDA	10531408
GO:0042562	Molecular function	Hormone binding	IPI	10531408
GO:0097159	Molecular function	Organic cyclic compound binding	IPI	10531408

Protein Information

Protein Name

Melatonin receptor type 1A, mel1a receptor

Function

High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity

UniProt

P48039

Pfam

Pfam Accession	Pfam ID
PF00001	7tm_1