NCOR1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

NCOR1

Aliases

N-CoR, N-CoR1, PPP1R109, TRAC1, hN-CoR

Entrez Gene ID

9611

Gene Name

Nuclear receptor corepressor 1

Chromosomal Location

17p12-p11.2

HGNC ID

HGNC:7672

Summary

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

RefSeq DNA

NG_047111.1

RefSeq mRNA

NM_006311.4, NM_001190438.1, NM_001190440.1

e!Ensembl

Gene	ENSG00000141027
Transcript	ENST00000268712, ENST00000395851, ENST00000395849, ENST00000579573, ENST00000603989, ENST00000580554, ENST00000579606, ENST00000436068, ENST00000395848, ENST00000411510, ENST00000582357, ENST00000436828, ENST00000460276, ENST00000430577, ENST00000395857
Protein	ENSP00000268712, ENSP00000379192, ENSP00000379190, ENSP00000461959, ENSP00000474008, ENSP00000463169, ENSP00000462281, ENSP00000389839, ENSP00000379189, ENSP00000407998, ENSP00000462308, ENSP00000387727, ENSP00000462794, ENSP00000410784, ENSP00000379198

Gene Ontology (GO)

Show/Hide all(37 )

GO ID	Ontology	Function	Evidence	Reference
GO:0000122	Biological process	Negative regulation of transcription by RNA polymerase II	IBA	21873635
GO:0000122	Biological process	Negative regulation of transcription by RNA polymerase II	IMP	12628926, 18052923, 19955185, 20388878
GO:0006366	Biological process	Transcription by RNA polymerase II	TAS	7566114
GO:0045892	Biological process	Negative regulation of transcription, DNA-templated	IMP	20812024
GO:0046329	Biological process	Negative regulation of JNK cascade	IDA	11931768
GO:0051225	Biological process	Spindle assembly	IMP	18326024
GO:0060766	Biological process	Negative regulation of androgen receptor signaling pathway	IMP	20812024
GO:0072362	Biological process	Regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter	IMP	19955185
GO:0072368	Biological process	Regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter	IMP	19955185
GO:1903799	Biological process	Negative regulation of production of miRNAs involved in gene silencing by miRNA	IMP	20388878
GO:2000191	Biological process	Regulation of fatty acid transport	IC	19955185
GO:0000118	Cellular component	Histone deacetylase complex	IBA	21873635
GO:0000118	Cellular component	Histone deacetylase complex	IDA	18326024
GO:0000790	Cellular component	Nuclear chromatin	IBA	21873635
GO:0000790	Cellular component	Nuclear chromatin	IDA	17505061, 20388878
GO:0005634	Cellular component	Nucleus	IBA	21873635
GO:0005634	Cellular component	Nucleus	IC	18052923
GO:0005634	Cellular component	Nucleus	IDA	10049357
GO:0016020	Cellular component	Membrane	HDA	19946888
GO:0016580	Cellular component	Sin3 complex	IBA	21873635
GO:0016580	Cellular component	Sin3 complex	IDA	11486045
GO:0017053	Cellular component	Transcriptional repressor complex	IBA	21873635
GO:0017053	Cellular component	Transcriptional repressor complex	IDA	11804585, 12628926
GO:0072686	Cellular component	Mitotic spindle	IDA	18326024
GO:0001012	Molecular function	RNA polymerase II regulatory region DNA binding	IBA	21873635
GO:0001102	Molecular function	RNA polymerase II activating transcription factor binding	IPI	19955185
GO:0003682	Molecular function	Chromatin binding	IBA	21873635
GO:0003714	Molecular function	Transcription corepressor activity	IBA	21873635
GO:0003714	Molecular function	Transcription corepressor activity	IDA	18052923
GO:0003714	Molecular function	Transcription corepressor activity	IMP	12628926, 15695367, 20812024
GO:0005515	Molecular function	Protein binding	IPI	10049357, 11013263, 11486045, 11931768, 12628926, 14525983, 16606617, 16980585, 17500595, 17519354, 17572682, 18952841, 19032343, 19955185, 20543827, 20581824, 20812024, 21258344, 21775429, 21988832, 23752268, 25303530, 26120082
GO:0035257	Molecular function	Nuclear hormone receptor binding	IBA	21873635
GO:0035257	Molecular function	Nuclear hormone receptor binding	IPI	9328355
GO:0042826	Molecular function	Histone deacetylase binding	IBA	21873635
GO:0042826	Molecular function	Histone deacetylase binding	IPI	11804585
GO:0043565	Molecular function	Sequence-specific DNA binding	IBA	21873635
GO:0046966	Molecular function	Thyroid hormone receptor binding	IBA	21873635

Protein Information

Protein Name

Nuclear receptor corepressor 1, protein phosphatase 1, regulatory subunit 109, thyroid hormone- and retinoic acid receptor-associated corepressor 1

Function

Mediates transcriptional repression by certain nuclear receptors (PubMed:20812024). Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors. Participates in the transcriptional repressor activity produced by BCL6. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024). Mediates the NR1D1-dependent repression and circadian regulation of TSHB expression (By similarity). The NCOR1-HDAC3 complex regulates the circadian expression of the core clock gene ARTNL/BMAL1 and the genes involved in lipid metabolism in the liver (By similarity).

Refseq Proteins

NP_006302.2, NP_001177367.1, NP_001177369.1

UniProt

O75376

PDB

3H52, 4MDD, 2EQR, 3KMZ, 3N00, 4WVD

Pfam

Pfam Accession	Pfam ID
PF15784	GPS2_interact
PF00249	Myb_DNA-binding