NGF: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

NGF

Aliases

Beta-NGF, HSAN5, NGFB

Entrez Gene ID

4803

Gene Name

Nerve growth factor

Chromosomal Location

1p13.2

HGNC ID

HGNC:7808

Summary

This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_007944.1

RefSeq mRNA

NM_002506.3, NM_002506.2

e!Ensembl

Gene	ENSG00000134259
Transcript	ENST00000369512
Protein	ENSP00000358525

Gene Ontology (GO)

Show/Hide all(27 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007169	Biological process	Transmembrane receptor protein tyrosine kinase signaling pathway	IBA	21873635
GO:0007422	Biological process	Peripheral nervous system development	IBA	21873635
GO:0007613	Biological process	Memory	IBA	21873635
GO:0008285	Biological process	Negative regulation of cell proliferation	TAS	10362258
GO:0008625	Biological process	Extrinsic apoptotic signaling pathway via death domain receptors	IDA	14985763
GO:0010628	Biological process	Positive regulation of gene expression	IMP	16153003
GO:0010628	Biological process	Positive regulation of gene expression	ISS	10362258
GO:0021675	Biological process	Nerve development	IBA	21873635
GO:0038180	Biological process	Nerve growth factor signaling pathway	IBA	21873635
GO:0043388	Biological process	Positive regulation of DNA binding	ISS	10362258
GO:0043524	Biological process	Negative regulation of neuron apoptotic process	IBA	21873635
GO:0045664	Biological process	Regulation of neuron differentiation	IBA	21873635
GO:0045666	Biological process	Positive regulation of neuron differentiation	TAS	10362258
GO:0048672	Biological process	Positive regulation of collateral sprouting	IBA	21873635
GO:0048812	Biological process	Neuron projection morphogenesis	IBA	21873635
GO:0048812	Biological process	Neuron projection morphogenesis	IDA	17724343
GO:0050804	Biological process	Modulation of chemical synaptic transmission	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0008021	Cellular component	Synaptic vesicle	IBA	21873635
GO:0030424	Cellular component	Axon	IBA	21873635
GO:0030425	Cellular component	Dendrite	IBA	21873635
GO:0031410	Cellular component	Cytoplasmic vesicle	IBA	21873635
GO:0005163	Molecular function	Nerve growth factor receptor binding	IBA	21873635
GO:0005163	Molecular function	Nerve growth factor receptor binding	IPI	14985763
GO:0005515	Molecular function	Protein binding	IPI	10490030, 14985763, 15131306, 18596692, 19122660
GO:0008083	Molecular function	Growth factor activity	IBA	21873635
GO:0008191	Molecular function	Metalloendopeptidase inhibitor activity	IDA	20164177

Protein Information

Protein Name

Beta-nerve growth factor, nerve growth factor (beta polypeptide), nerve growth factor, beta subunit, pro-nerve growth factor long

Function

Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival. The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI. Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form

Refseq Proteins

NP_002497.2

UniProt

P01138

PDB

1SG1, 1WWW, 2IFG, 4EDW, 4EDX, 4ZBN, 5JZ7

Pfam

Pfam Accession	Pfam ID
PF00243	NGF