NOS2: Polycystic Ovarian Syndrome Database

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NOS2

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

NOS2

Aliases

HEP-NOS, INOS, NOS, NOS2A

Entrez Gene ID

4843

Gene Name

Nitric oxide synthase 2

Chromosomal Location

17q11.2

HGNC ID

HGNC:7873

Summary

Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. This gene encodes a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. Three related pseudogenes are located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_011470.1

RefSeq mRNA

NM_000625.4

e!Ensembl

Gene	ENSG00000007171
Transcript	ENST00000313735, ENST00000646938, ENST00000621962
Protein	ENSP00000327251, ENSP00000494870, ENSP00000482291

Gene Ontology (GO)

Show/Hide all(39 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001912	Biological process	Positive regulation of leukocyte mediated cytotoxicity	TAS	10450191
GO:0002227	Biological process	Innate immune response in mucosa	NAS	18390757
GO:0006527	Biological process	Arginine catabolic process	IBA	21873635
GO:0006527	Biological process	Arginine catabolic process	IDA	7504305
GO:0006809	Biological process	Nitric oxide biosynthetic process	IBA	21873635
GO:0006809	Biological process	Nitric oxide biosynthetic process	IDA	7504305, 7682706
GO:0007263	Biological process	Nitric oxide mediated signal transduction	IBA	21873635
GO:0009617	Biological process	Response to bacterium	NAS	12085352
GO:0009725	Biological process	Response to hormone	IBA	21873635
GO:0010629	Biological process	Negative regulation of gene expression	IGI	12085352
GO:0031284	Biological process	Positive regulation of guanylate cyclase activity	IBA	21873635
GO:0032310	Biological process	Prostaglandin secretion	IDA	19688109
GO:0032496	Biological process	Response to lipopolysaccharide	IBA	21873635
GO:0042742	Biological process	Defense response to bacterium	IBA	21873635
GO:0042742	Biological process	Defense response to bacterium	IMP	9284131
GO:0043457	Biological process	Regulation of cellular respiration	TAS	10450191
GO:0045776	Biological process	Negative regulation of blood pressure	IBA	21873635
GO:0050796	Biological process	Regulation of insulin secretion	IMP	8383325
GO:0050829	Biological process	Defense response to Gram-negative bacterium	NAS	18390757
GO:0051712	Biological process	Positive regulation of killing of cells of other organism	IMP	7544003
GO:0072604	Biological process	Interleukin-6 secretion	IDA	19688109
GO:0072606	Biological process	Interleukin-8 secretion	IDA	19688109
GO:1900015	Biological process	Regulation of cytokine production involved in inflammatory response	IDA	19688109
GO:0005634	Cellular component	Nucleus	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IDA	9916929, 12085352
GO:0005777	Cellular component	Peroxisome	IDA	12085352
GO:0005829	Cellular component	Cytosol	IBA	21873635
GO:0005829	Cellular component	Cytosol	IMP	7504305
GO:0005886	Cellular component	Plasma membrane	IBA	21873635
GO:0012506	Cellular component	Vesicle membrane	IBA	21873635
GO:0003958	Molecular function	NADPH-hemoprotein reductase activity	IBA	21873635
GO:0004517	Molecular function	Nitric-oxide synthase activity	IBA	21873635
GO:0004517	Molecular function	Nitric-oxide synthase activity	IDA	7504305, 7682706
GO:0005102	Molecular function	Signaling receptor binding	IPI	20178365
GO:0005515	Molecular function	Protein binding	IPI	12855682, 21199876, 25417112
GO:0010181	Molecular function	FMN binding	IBA	21873635
GO:0016491	Molecular function	Oxidoreductase activity	IBA	21873635
GO:0050660	Molecular function	Flavin adenine dinucleotide binding	IBA	21873635
GO:0050661	Molecular function	NADP binding	TAS	7504305

Protein Information

Protein Name

Nitric oxide synthase, inducible, NOS, type II, hepatocyte NOS, inducible NO synthase, inducible NOS, nitric oxide synthase 2, inducible, nitric oxide synthase 2A (inducible, hepatocytes), nitric oxide synthase, macrophage, peptidyl-cysteine S-nitrosylase NOS2

Function

Refseq Proteins

NP_000616.3

UniProt

P35228

PDB

2LL6, 3HR4, 5TP6, 1NSI, 2NSI, 3E7G, 3EJ8, 4CX7, 4NOS, 5XN3

Pathways
	KEGG	Reactome
	Arginine biosynthesis Arginine and proline metabolism Metabolic pathways Calcium signaling pathway HIF-1 signaling pathway Peroxisome Apelin signaling pathway Relaxin signaling pathway Salmonella infection Pertussis Leishmaniasis Chagas disease (American trypanosomiasis) Toxoplasmosis Amoebiasis Tuberculosis Pathways in cancer Small cell lung cancer	ROS and RNS production in phagocytes Nitric oxide stimulates guanylate cyclase Interleukin-4 and Interleukin-13 signaling Peroxisomal protein import Inhibition of nitric oxide production

Interactions

STRING	MINT	IntAct
ENSP00000338864		Q7LDG7

View interactions

Associated Diseases

Show/Hide all(16 )

Disease group	Disease Name	References
Cardiovascular Diseases
	Myocardial Infarction	10090345, 11489778
	Heart Failure	19168511
	Cardiovascular Abnormalities	19587355
	Hypertensive disease	18605955, 27292124, 25101153
	Myocardial Stunning	11927517
	Atherosclerosis	20720404
	Aortitis Syndrome	25101153
	Hibernating Myocardium	11927517
	Takayasu Arteritis	25101153
	Myocardial Failure	19168511
	Hyperemia	12646421
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
	Hemorrhages	17053178
	Atonic seizures	19559095
	Turner Syndrome	25101153
	Marfan Syndrome	25101153
Digestive System Diseases
	Duodenal Ulcer	12481160, 17045617
	Gastric ulcer	15138204, 12481160, 19066340, 17045617
	Enterocolitis	17923197
	Colitis	17449036, 8698225, 26974007
	Cholestasis	12612912, 20626112
	Intestinal Diseases	11713966
	Cholangitis	12612912, 26974007
	Crohn Disease	26974007
	Liver Diseases	19784758
Ear Or Mastoid Diseases
Ear Or Mastoid Diseases	Meniere Disease	28787010
Endocrine System Diseases
	Diabetes Mellitus	16959961
	PCOS	26132931
Eye Diseases
Eye Diseases	Retinal Diseases	23075401
Immune System Diseases
Immune System Diseases	Stevens-Johnson Syndrome	10620138
Musculoskeletal Diseases
	Arthritis, Psoriatic	20953189
	Spondylitis	23749187, 26974007
Neoplasms
	Breast Cancer	15631943, 16959974
	Colonic Neoplasms	16105666, 21081470
	Esophagus Neoplasm	15264214
	Lung Cancer	12460898, 22369883
	Extrahepatic Cholangiocarcinoma	16818635
	Intrahepatic Cholangiocarcinoma	16818635
	Cholangiocarcinoma	16818635
Nervous System Diseases
	Parkinson Disease	25634431
	Cerebral Ischemia	17394460, 9778187
	Seizures	19559095
	Stroke	20083630
	Ischemic Encephalopathy	23694759
	Status Epilepticus	20149694
	Cerebral Edema	19374494
	Petit mal status	20149694
	Jacksonian Seizure	19559095
Nutritional and Metabolic Diseases
Nutritional and Metabolic Diseases	Mitochondrial Diseases	16157314
Psychiatric/Brain disorders
	Mental Depression	21750947, 21630437, 19571147, 22989585, 22959237
	Autistic Disorder	18563708
	Obstructive Sleep Apnea	24010499, 16554025
Renal Disorder
	Glomerulosclerosis	16191423
	Kidney Insufficiency	9810145
	Kidney Failure	9810145
	Glomerular Hyalinosis	16191423
Reproductive disorders
Reproductive disorders	Urinary tract infection	9011564
Respiratory Tract Diseases
	Asthma	19800904
	Pulmonary Fibrosis	12160931
	Bronchial Diseases	15774269
	Airway Obstruction	21843929
	Mendelson Syndrome	15607125
	Chronic Obstructive Pulmonary Disease	21843929
	Pneumonia	15607125
	Pulmonary asbestosis	12160931
	Silicosis	15292275
Skin and Connective Tissue Diseases
	Psoriasis	23143594, 20953189, 25574825, 25903422, 26974007, 26626624
	Pustulosis	20953189

References

PMID: 26132931

Inflammation and Human Ovarian Follicular Dynamics.

Boots Christina E, Jungheim Emily S

Department of Obstetrics and Gynecology, Washington University, St. Louis, Missouri.| Department of Obstetrics and Gynecology, Washington University, St. Louis, Missouri.

Semin Reprod Med. 2015 Jul;33(4):270-5. doi: 10.1055/s-0035-1554928. Epub 2015

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