NPPB: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

NPPB

Aliases

BNP

Entrez Gene ID

4879

Gene Name

Natriuretic peptide B

Chromosomal Location

1p36.22

HGNC ID

HGNC:7940

Summary

This gene is a member of the natriuretic peptide family and encodes a secreted protein which functions as a cardiac hormone. The protein undergoes two cleavage events, one within the cell and a second after secretion into the blood. The protein's biological actions include natriuresis, diuresis, vasorelaxation, inhibition of renin and aldosterone secretion, and a key role in cardiovascular homeostasis. A high concentration of this protein in the bloodstream is indicative of heart failure. The protein also acts as an antimicrobial peptide with antibacterial and antifungal activity. Mutations in this gene have been associated with postmenopausal osteoporosis. [provided by RefSeq, Nov 2014]

e!Ensembl

Gene	ENSG00000120937
Transcript	ENST00000376468
Protein	ENSP00000365651

Gene Ontology (GO)

Show/Hide all(31 )

GO ID	Ontology	Function	Evidence	Reference
GO:0003085	Biological process	Negative regulation of systemic arterial blood pressure	IBA	21873635
GO:0006182	Biological process	CGMP biosynthetic process	IBA	21873635
GO:0006182	Biological process	CGMP biosynthetic process	IDA	1672777
GO:0006457	Biological process	Protein folding	IDA	16870210
GO:0007166	Biological process	Cell surface receptor signaling pathway	NAS	12727915
GO:0007168	Biological process	Receptor guanylyl cyclase signaling pathway	IBA	21873635
GO:0007168	Biological process	Receptor guanylyl cyclase signaling pathway	IDA	1672777
GO:0007218	Biological process	Neuropeptide signaling pathway	IBA	21873635
GO:0007589	Biological process	Body fluid secretion	TAS	14960748
GO:0008217	Biological process	Regulation of blood pressure	NAS	12727915
GO:0016525	Biological process	Negative regulation of angiogenesis	TAS	14737067
GO:0019934	Biological process	CGMP-mediated signaling	IBA	21873635
GO:0030308	Biological process	Negative regulation of cell growth	NAS	12727915
GO:0035810	Biological process	Positive regulation of urine volume	TAS	14737067
GO:0035815	Biological process	Positive regulation of renal sodium excretion	TAS	14960748
GO:0043114	Biological process	Regulation of vascular permeability	TAS	14737067
GO:0097746	Biological process	Regulation of blood vessel diameter	NAS	7601467
GO:0005576	Cellular component	Extracellular region	TAS	14960748
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005615	Cellular component	Extracellular space	NAS	7601467
GO:0005634	Cellular component	Nucleus	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IBA	21873635
GO:0032991	Cellular component	Protein-containing complex	IDA	16870210, 23382219
GO:0005102	Molecular function	Signaling receptor binding	IDA	1672777
GO:0005102	Molecular function	Signaling receptor binding	IPI	12727915, 16870210
GO:0005179	Molecular function	Hormone activity	IBA	21873635
GO:0005179	Molecular function	Hormone activity	NAS	7601467
GO:0005515	Molecular function	Protein binding	IPI	25416956
GO:0008613	Molecular function	Diuretic hormone activity	TAS	14960748
GO:0051427	Molecular function	Hormone receptor binding	IBA	21873635
GO:0051427	Molecular function	Hormone receptor binding	IPI	1660465

Protein Information

Protein Name

Natriuretic peptides B, brain type natriuretic peptide, gamma-brain natriuretic peptide, natriuretic peptide precursor B, natriuretic protein

Function

Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

UniProt

P16860

PDB

1YK1, 3N56

Pfam

Pfam Accession	Pfam ID
PF00212	ANP