NR4A1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

NR4A1

Aliases

GFRP1, HMR, N10, NAK-1, NGFIB, NP10, NUR77, TR3

Entrez Gene ID

3164

Gene Name

Nuclear receptor subfamily 4 group A member 1

Chromosomal Location

12q13.13

HGNC ID

HGNC:7980

Summary

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

e!Ensembl

Gene	ENSG00000123358
Transcript	ENST00000548977, ENST00000546842, ENST00000553200, ENST00000545748, ENST00000550082, ENST00000550763, ENST00000394824, ENST00000548232, ENST00000562373, ENST00000550582, ENST00000394825, ENST00000360284, ENST00000243050
Protein	ENSP00000456633, ENSP00000457070, ENSP00000456776, ENSP00000440864, ENSP00000449539, ENSP00000449858, ENSP00000378301, ENSP00000449587, ENSP00000455399, ENSP00000455767, ENSP00000378302, ENSP00000353427, ENSP00000243050

Gene Ontology (GO)

Show/Hide all(17 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001938	Biological process	Positive regulation of endothelial cell proliferation	IMP	18059339
GO:0002042	Biological process	Cell migration involved in sprouting angiogenesis	IDA	18059339
GO:0007165	Biological process	Signal transduction	TAS	2626032
GO:0035767	Biological process	Endothelial cell chemotaxis	IMP	18059339
GO:0035924	Biological process	Cellular response to vascular endothelial growth factor stimulus	IMP	18059339
GO:0044344	Biological process	Cellular response to fibroblast growth factor stimulus	IMP	18059339
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IDA	22427340
GO:0071376	Biological process	Cellular response to corticotropin-releasing hormone stimulus	IBA	21873635
GO:0005634	Cellular component	Nucleus	IBA	21873635
GO:0005667	Cellular component	Transcription factor complex	IBA	21873635
GO:0000977	Molecular function	RNA polymerase II regulatory region sequence-specific DNA binding	IBA	21873635
GO:0000978	Molecular function	RNA polymerase II proximal promoter sequence-specific DNA binding	IBA	21873635
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISM	19274049
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	NAS	19274049
GO:0005515	Molecular function	Protein binding	IPI	17139261, 18305892, 18835031, 18985028, 19095693, 20195357, 21988832, 22761572, 24139859, 25416956
GO:0035259	Molecular function	Glucocorticoid receptor binding	IBA	21873635
GO:0043565	Molecular function	Sequence-specific DNA binding	IBA	21873635

Protein Information

Protein Name

Nuclear receptor subfamily 4 group A member 1, ST-59, TR3 orphan receptor, early response protein NAK1, growth factor-inducible nuclear protein N10, hormone receptor, nerve growth factor IB nuclear receptor variant 1, nuclear hormone receptor NUR/77, orphan nuclear receptor HMR, orphan nuclear receptor TR3, steroid receptor TR3, testicular receptor 3

Function

UniProt

P22736

PDB

2QW4, 3V3E, 3V3Q, 4JGV, 4KZI, 4KZJ, 4KZM, 4RE8, 4REE, 4REF, 4RZE, 4RZF, 4RZG, 4WHF, 4WHG

Pfam

Pfam Accession	Pfam ID
PF00104	Hormone_recep
PF00105	zf-C4