NUCB2: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

NUCB2

Aliases

HEL-S-109, NEFA

Entrez Gene ID

4925

Gene Name

Nucleobindin 2

Chromosomal Location

11p15.1

HGNC ID

HGNC:8044

Summary

This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011]

e!Ensembl

Gene	ENSG00000070081
Transcript	ENST00000528644, ENST00000646648, ENST00000530527, ENST00000526120, ENST00000533773, ENST00000531172, ENST00000533738, ENST00000323688, ENST00000529010, ENST00000530964, ENST00000529313, ENST00000533926, ENST00000527580, ENST00000527735, ENST00000622082, ENST00000458064
Protein	ENSP00000431136, ENSP00000495210, ENSP00000435160, ENSP00000436215, ENSP00000433542, ENSP00000435968, ENSP00000435558, ENSP00000320168, ENSP00000436455, ENSP00000431328, ENSP00000431334, ENSP00000433194, ENSP00000435787, ENSP00000432741, ENSP00000481959, ENSP00000408702

SNPs

SNP Id	Upstream Sequence	SNP	Downstream Sequence	Functional Significance	References
rs757081					26369257

Gene Ontology (GO)

Show/Hide all(8 )

GO ID	Ontology	Function	Evidence	Reference
GO:0005615	Cellular component	Extracellular space	HDA	16502470
GO:0005793	Cellular component	Endoplasmic reticulum-Golgi intermediate compartment	IBA	21873635
GO:0005793	Cellular component	Endoplasmic reticulum-Golgi intermediate compartment	IDA	15308636
GO:0005829	Cellular component	Cytosol	TAS	7811391
GO:0005886	Cellular component	Plasma membrane	TAS	7811391
GO:0070062	Cellular component	Extracellular exosome	HDA	19199708
GO:0005509	Molecular function	Calcium ion binding	IBA	21873635
GO:0005515	Molecular function	Protein binding	IPI	21988832

Protein Information

Protein Name

Nucleobindin-2, DNA-binding protein NEFA, epididymis secretory protein Li 109, gastric cancer antigen Zg4, nesfatin 1, novel DNA binding/EF-hand/leucine zipper protein, nucleobinding 2, prepronesfatin

Function

Calcium-binding protein which may have a role in calcium homeostasis (By similarity). Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3 (By similarity). .; [Nesfatin-1]: Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance.

UniProt

P80303

Pfam

Pfam Accession	Pfam ID
PF13499	EF-hand_7