OGT: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

OGT

Aliases

HINCUT-1, HRNT1, MRX106, O-GLCNAC, OGT1

Entrez Gene ID

8473

Gene Name

O-linked N-acetylglucosamine (GlcNAc) transferase

Chromosomal Location

Xq13.1

HGNC ID

HGNC:8127

Summary

This gene encodes a glycosyltransferase that catalyzes the addition of a single N-acetylglucosamine in O-glycosidic linkage to serine or threonine residues. Since both phosphorylation and glycosylation compete for similar serine or threonine residues, the two processes may compete for sites, or they may alter the substrate specificity of nearby sites by steric or electrostatic effects. The protein contains multiple tetratricopeptide repeats that are required for optimal recognition of substrates. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

RefSeq DNA

NG_015875.1

RefSeq mRNA

NM_181673.3, NM_181672.3

e!Ensembl

Gene	ENSG00000147162
Transcript	ENST00000373719, ENST00000373701, ENST00000444774
Protein	ENSP00000362824, ENSP00000362805, ENSP00000399729

Gene Ontology (GO)

Show/Hide all(40 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006110	Biological process	Regulation of glycolytic process	IDA	22923583
GO:0006357	Biological process	Regulation of transcription by RNA polymerase II	IMP	26678539
GO:0006493	Biological process	Protein O-linked glycosylation	IBA	21873635
GO:0006493	Biological process	Protein O-linked glycosylation	IDA	21240259, 21285374, 22923583, 23222540, 23352454, 24474760
GO:0006493	Biological process	Protein O-linked glycosylation	IMP	23353889
GO:0006915	Biological process	Apoptotic process	IDA	20824293
GO:0007165	Biological process	Signal transduction	TAS	9083067
GO:0007584	Biological process	Response to nutrient	TAS	9083068
GO:0016485	Biological process	Protein processing	IMP	28584052
GO:0031397	Biological process	Negative regulation of protein ubiquitination	IMP	26678539
GO:0032435	Biological process	Negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP	26678539
GO:0032868	Biological process	Response to insulin	IDA	18288188
GO:0035020	Biological process	Regulation of Rac protein signal transduction	IDA	18288188
GO:0043981	Biological process	Histone H4-K5 acetylation	IDA	20018852
GO:0043982	Biological process	Histone H4-K8 acetylation	IDA	20018852
GO:0043984	Biological process	Histone H4-K16 acetylation	IDA	20018852
GO:0045862	Biological process	Positive regulation of proteolysis	IDA	21285374
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IDA	23222540, 23353889
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IMP	23352454
GO:0046626	Biological process	Regulation of insulin receptor signaling pathway	IDA	18288188
GO:0048015	Biological process	Phosphatidylinositol-mediated signaling	IDA	18288188
GO:0061087	Biological process	Positive regulation of histone H3-K27 methylation	IMP	24474760
GO:0080182	Biological process	Histone H3-K4 trimethylation	IMP	23353889
GO:0120162	Biological process	Positive regulation of cold-induced thermogenesis	ISS	28637651
GO:0000123	Cellular component	Histone acetyltransferase complex	IDA	20018852
GO:0005634	Cellular component	Nucleus	IDA	21285374, 26678539
GO:0005829	Cellular component	Cytosol	IDA	21285374
GO:0005886	Cellular component	Plasma membrane	IDA	18288188
GO:0017122	Cellular component	Protein N-acetylglucosaminyltransferase complex	IDA	21240259
GO:0032991	Cellular component	Protein-containing complex	IDA	26678539
GO:0005515	Molecular function	Protein binding	IPI	12150998, 12670868, 16189514, 17882263, 20200153, 21285374, 21295698, 22923583, 23088713, 23222540, 23353889, 23629655, 24474760, 24995978, 25416956, 25419848, 26678539, 27505673, 27705803
GO:0005547	Molecular function	Phosphatidylinositol-3,4,5-trisphosphate binding	IDA	18288188
GO:0008375	Molecular function	Acetylglucosaminyltransferase activity	TAS	9083068
GO:0016262	Molecular function	Protein N-acetylglucosaminyltransferase activity	IBA	21873635
GO:0016262	Molecular function	Protein N-acetylglucosaminyltransferase activity	IDA	21240259, 21285374, 22923583, 23222540, 23352454, 23353889, 24474760
GO:0016262	Molecular function	Protein N-acetylglucosaminyltransferase activity	IMP	26678539
GO:0043995	Molecular function	Histone acetyltransferase activity (H4-K5 specific)	IDA	20018852
GO:0043996	Molecular function	Histone acetyltransferase activity (H4-K8 specific)	IDA	20018852
GO:0046972	Molecular function	Histone acetyltransferase activity (H4-K16 specific)	IDA	20018852
GO:0097363	Molecular function	Protein O-GlcNAc transferase activity	IMP	23777819, 28584052

Protein Information

Protein Name

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit, O-GlcNAc transferase p110 subunit, O-GlcNAc transferase subunit p110, O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase), O-linked N-acetylglucosamine transferase 110 kDa subunit, UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase, uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyl transferase

Function

Refseq Proteins

NP_858059.1, NP_858058.1

UniProt

O15294

PDB

3PE4, 3TAX, 4GYW, 4GYY, 4GZ3, 5HGV, 5VIE, 5VIF, 4N39, 4N3A, 4N3B, 4N3C, 5LWV, 6MA1, 6MA2, 6MA3, 6MA4, 6MA5, 4XIF, 5BNW, 1W3B, 3PE3, 4AY5, 4AY6, 4CDR, 4GZ5, 4GZ6, 4XI9, 5C1D, 5LVV, 5NPR, 5NPS, 6EOU

Pfam

Pfam Accession	Pfam ID
PF13844	Glyco_transf_41
PF00515	TPR_1
PF13181	TPR_8

OGT

Gene expression microarray profiles of cumulus cells in lean and overweight-obese polycystic ovary syndrome patients.