PDCD4: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

PDCD4

Aliases

H731

Entrez Gene ID

27250

Gene Name

Programmed cell death 4

Chromosomal Location

10q25.2

HGNC ID

HGNC:8763

Summary

This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]

e!Ensembl

Gene	ENSG00000150593
Transcript	ENST00000280154, ENST00000444997, ENST00000393104
Protein	ENSP00000280154, ENSP00000394668, ENSP00000376816

Gene Ontology (GO)

Show/Hide all(17 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006915	Biological process	Apoptotic process	NAS	12054647
GO:0007569	Biological process	Cell aging	IDA	12054647
GO:0030509	Biological process	BMP signaling pathway	IDA	18548003
GO:0045786	Biological process	Negative regulation of cell cycle	NAS	12054647
GO:0045892	Biological process	Negative regulation of transcription, DNA-templated	IDA	16357133
GO:1901224	Biological process	Positive regulation of NIK/NF-kappaB signaling	IMP	19946272
GO:1904706	Biological process	Negative regulation of vascular smooth muscle cell proliferation	IMP	28522568
GO:1904761	Biological process	Negative regulation of myofibroblast differentiation	IMP	20533548
GO:1905064	Biological process	Negative regulation of vascular smooth muscle cell differentiation	IDA	18548003
GO:1905461	Biological process	Positive regulation of vascular associated smooth muscle cell apoptotic process	IMP	28522568
GO:2000353	Biological process	Positive regulation of endothelial cell apoptotic process	IMP	24732886
GO:0005634	Cellular component	Nucleus	IBA	21873635
GO:0005634	Cellular component	Nucleus	IMP	16357133
GO:0005737	Cellular component	Cytoplasm	IMP	16357133
GO:0005829	Cellular component	Cytosol	IBA	21873635
GO:0005829	Cellular component	Cytosol	IDA	12054647
GO:0005515	Molecular function	Protein binding	IPI	12054647, 16357133, 18296639, 19204291, 21163940, 24413684, 25416956

Protein Information

Protein Name

Programmed cell death protein 4, neoplastic transformation inhibitor protein, nuclear antigen H731, programmed cell death 4 (neoplastic transformation inhibitor), protein 197/15a

Function

Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).

UniProt

Q53EL6

PDB

2ZU6, 2GGF, 2KZT, 2RG8, 3EIJ

Pfam

Pfam Accession	Pfam ID
PF02847	MA3