Gene Information
Gene Symbol
Entrez Gene ID
Gene Name
Platelet derived growth factor receptor alpha
Chromosomal Location
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers. [provided by RefSeq, Mar 2012]
RefSeq DNA
RefSeq mRNA

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0001775 Biological process Cell activation TAS 10508235
GO:0002244 Biological process Hematopoietic progenitor cell differentiation IBA 21873635
GO:0007169 Biological process Transmembrane receptor protein tyrosine kinase signaling pathway IBA 21873635
GO:0007204 Biological process Positive regulation of cytosolic calcium ion concentration IMP 2554309
GO:0008284 Biological process Positive regulation of cell proliferation IBA 21873635
Protein Information
Protein Name
Platelet-derived growth factor receptor alpha, CD140 antigen-like family member A, CD140a antigen, PDGF-R-alpha, alpha-type platelet-derived growth factor receptor, platelet-derived growth factor receptor 2, platelet-derived growth factor receptor, alpha polypeptide
Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal development of the mucosa lining the gastrointestinal tract, and for recruitment of mesenchymal cells and normal development of intestinal villi. Plays a role in cell migration and chemotaxis in wound healing. Plays a role in platelet activation, secretion of agonists from platelet granules, and in thrombin-induced platelet aggregation. Binding of its cognate ligands - homodimeric PDGFA, homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGFC -leads to the activation of several signaling cascades; the response depends on the nature of the bound ligand and is modulated by the formation of heterodimers between PDGFRA and PDGFRB. Phosphorylates PIK3R1, PLCG1, and PTPN11. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate, mobilization of cytosolic Ca(2+) and the activation of protein kinase C. Phosphorylates PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and thereby mediates activation of the AKT1 signaling pathway. Mediates activation of HRAS and of the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. Promotes activation of STAT family members STAT1, STAT3 and STAT5A and/or STAT5B. Receptor signaling is down-regulated by protein phosphatases that dephosphorylate the receptor and its down-stream effectors, and by rapid internalization of the activated receptor.
Refseq Proteins
Pfam Accession Pfam ID
PF07679 I-set
PF07714 Pkinase_Tyr

EGFR tyrosine kinase inhibitor resistance
MAPK signaling pathway
Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
Phospholipase D signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
Gap junction
JAK-STAT signaling pathway
Regulation of actin cytoskeleton
Human cytomegalovirus infection
Pathways in cancer
MicroRNAs in cancer
Prostate cancer
Central carbon metabolism in cancer
Choline metabolism in cancer


PIP3 activates AKT signaling
Downstream signal transduction
Signaling by PDGF
Constitutive Signaling by Aberrant PI3K in Cancer
RAF/MAP kinase cascade
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants
Signaling by PDGFRA extracellular domain mutants
Imatinib-resistant PDGFR mutants
Sunitinib-resistant PDGFR mutants
Regorafenib-resistant PDGFR mutants
Sorafenib-resistant PDGFR mutants
PDGFR mutants bind TKIs

ENSP00000354720 Q9UQE7 Q9UQE7
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Associated Diseases

Disease groupDisease NameReferences
Blood Disorders
Hypereosinophilic syndrome
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
Cleft palate
Status Dysraphicus
Congenital abnormality of respiratory system

PDGFRA, HSD17B4 and HMGB2 are potential therapeutic targets in polycystic ovarian syndrome and breast cancer.

Xu Huiyu, Han Yong, Lou Jiaying, Zhang Hongxian, Zhao Yue, Gyorffy Balazs, Li Rong
Department of Obstetrics and Gynecology, Reproductive Medical Center, Peking University Third Hospital, Beijing, P.R. China.| Department of Pathology, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang Province, P.R. China.| Department of Clinical Laboratory, Renmin Hospital of Xiaoshan District, Hangzhou, Zhejiang Province, P.R. China.| Department of Urology, Peking University Third Hospital, Beijing, P.R. China.| Department of Obstetrics and Gynecology, Reproductive Medical Center, Peking University Third Hospital, Beijing, P.R. China.| Momentum Cancer Biomarker Research Group, Research Centre for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary.| Second Department of Pediatrics, Semmelweis University, Budapest, Hungary.| Department of Obstetrics and Gynecology, Reproductive Medical Center, Peking University Third Hospital, Beijing, P.R. China.
Oncotarget. 2017 May 13;8(41):69520-69526. doi: 10.18632/oncotarget.17846.

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