PECAM1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

PECAM1

Entrez Gene ID

5175

Gene Name

Platelet and endothelial cell adhesion molecule 1

Chromosomal Location

17q23.3

HGNC ID

HGNC:8823

Summary

The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation. [provided by RefSeq, May 2010]

RefSeq DNA

NG_047009.1

RefSeq mRNA

NM_000442.5

e!Ensembl

Gene	ENSG00000261371
Transcript	ENST00000563924, ENST00000564866, ENST00000563523, ENST00000569967
Protein	ENSP00000457421, ENSP00000455663, ENSP00000455931, ENSP00000457218

Gene Ontology (GO)

Show/Hide all(15 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006909	Biological process	Phagocytosis	IDA	12110892
GO:0007156	Biological process	Homophilic cell adhesion via plasma membrane adhesion molecules	IMP	27958302
GO:0007159	Biological process	Leukocyte cell-cell adhesion	IMP	17580308
GO:0007165	Biological process	Signal transduction	TAS	7994021
GO:0008037	Biological process	Cell recognition	TAS	1690453
GO:0035696	Biological process	Monocyte extravasation	IMP	11078691
GO:0050904	Biological process	Diapedesis	IDA	19342684
GO:0072011	Biological process	Glomerular endothelium development	IEP	17464107
GO:0072672	Biological process	Neutrophil extravasation	IMP	17580308, 22266279
GO:0098742	Biological process	Cell-cell adhesion via plasma-membrane adhesion molecules	IMP	17580308
GO:0005615	Cellular component	Extracellular space	IDA	9290466
GO:0005886	Cellular component	Plasma membrane	IDA	17464107
GO:0070062	Cellular component	Extracellular exosome	HDA	20458337
GO:0005515	Molecular function	Protein binding	IPI	9162084, 9312087, 9774457, 10704309, 10801826, 17580308, 18672896, 25241761
GO:0042803	Molecular function	Protein homodimerization activity	IDA	26702061, 27958302

Protein Information

Protein Name

Platelet endothelial cell adhesion molecule, CD31 antigen, platelet endothelial cell adhesion molecule-1

Function

Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions (PubMed:19342684, PubMed:17580308). Tyr-690 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes (PubMed:19342684). Trans-homophilic interaction may play a role in endothelial cell-cell adhesion via cell junctions (PubMed:27958302). Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils (PubMed:17580308). Homophilic ligation of PECAM1 prevents macrophage-mediated phagocytosis of neighboring viable leukocytes by transmitting a detachment signal (PubMed:12110892). Promotes macrophage-mediated phagocytosis of apoptotic leukocytes by tethering them to the phagocytic cells; PECAM1-mediated detachment signal appears to be disabled in apoptotic leukocytes (PubMed:12110892). Modulates bradykinin receptor BDKRB2 activation (PubMed:18672896). Regulates bradykinin- and hyperosmotic shock-induced ERK1/2 activation in endothelial cells (PubMed:18672896). Induces susceptibility to atherosclerosis (By similarity). .; [Isoform Delta15]: Does not protect against apoptosis.

Refseq Proteins

NP_000433.4

UniProt

P16284

PDB

2KY5, 5C14, 5GNI