PF4: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

PF4

Aliases

CXCL4, PF-4, SCYB4

Entrez Gene ID

5196

Gene Name

Platelet factor 4

Chromosomal Location

4q13.3

HGNC ID

HGNC:8861

Summary

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function. The protein also exhibits antimicrobial activity against Plasmodium falciparum. [provided by RefSeq, Oct 2014]

RefSeq DNA

NG_032897.1

RefSeq mRNA

NM_002619.4, NM_001363352.1

e!Ensembl

Gene	ENSG00000163737
Transcript	ENST00000296029
Protein	ENSP00000296029

Gene Ontology (GO)

Show/Hide all(36 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006954	Biological process	Inflammatory response	IBA	21873635
GO:0006955	Biological process	Immune response	IBA	21873635
GO:0007189	Biological process	Adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA	12782716
GO:0010628	Biological process	Positive regulation of gene expression	IDA	10666185
GO:0010744	Biological process	Positive regulation of macrophage derived foam cell differentiation	IDA	17244792
GO:0016525	Biological process	Negative regulation of angiogenesis	IDA	1688470
GO:0019221	Biological process	Cytokine-mediated signaling pathway	IDA	12041672
GO:0030168	Biological process	Platelet activation	IDA	11685038
GO:0030593	Biological process	Neutrophil chemotaxis	IBA	21873635
GO:0030595	Biological process	Leukocyte chemotaxis	IBA	21873635
GO:0030595	Biological process	Leukocyte chemotaxis	IDA	6945600
GO:0032760	Biological process	Positive regulation of tumor necrosis factor production	IDA	10666185
GO:0042127	Biological process	Regulation of cell proliferation	IDA	12782716
GO:0042832	Biological process	Defense response to protozoan	IDA	23245326
GO:0045347	Biological process	Negative regulation of MHC class II biosynthetic process	IDA	10666185
GO:0045651	Biological process	Positive regulation of macrophage differentiation	IDA	10666185
GO:0045653	Biological process	Negative regulation of megakaryocyte differentiation	IDA	2140694
GO:0045918	Biological process	Negative regulation of cytolysis	IDA	10666185
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IDA	12782716
GO:0051873	Biological process	Killing by host of symbiont cells	IDA	23245326
GO:0061844	Biological process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IBA	21873635
GO:0061844	Biological process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IDA	23245326
GO:0070098	Biological process	Chemokine-mediated signaling pathway	IBA	21873635
GO:0071222	Biological process	Cellular response to lipopolysaccharide	IBA	21873635
GO:2001240	Biological process	Negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	IDA	10666185
GO:0005576	Cellular component	Extracellular region	NAS	14718574
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IDA	23245326
GO:0020005	Cellular component	Symbiont-containing vacuole membrane	IDA	23245326
GO:0062023	Cellular component	Collagen-containing extracellular matrix	HDA	28344315
GO:0097679	Cellular component	Other organism cytoplasm	IDA	23245326
GO:0005515	Molecular function	Protein binding	IPI	19805618, 28381538
GO:0008009	Molecular function	Chemokine activity	IBA	21873635
GO:0008009	Molecular function	Chemokine activity	TAS	12466273
GO:0008201	Molecular function	Heparin binding	IDA	9531587
GO:0048248	Molecular function	CXCR3 chemokine receptor binding	IDA	12782716

Protein Information

Protein Name

Platelet factor 4, C-X-C motif chemokine 4, chemokine (C-X-C motif) ligand 4, iroplact, oncostatin-A

Function

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.

Refseq Proteins

NP_002610.1, NP_001350281.1

UniProt

P02776

PDB

1DN3, 1F9Q, 1F9R, 1F9S, 1PFM, 1PFN, 1RHP, 4R9W, 4R9Y, 4RAU

Pfam

Pfam Accession	Pfam ID
PF00048	IL8