PGR: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

PGR

Aliases

NR3C3, PR

Entrez Gene ID

5241

Gene Name

Progesterone receptor

Chromosomal Location

11q22.1

HGNC ID

HGNC:8910

Summary

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]

RefSeq DNA

NG_016475.1

RefSeq mRNA

NM_000926.4, NR_073141.2, NR_073142.2, NR_073143.2, NM_001202474.3, NM_001271161.2, NM_001271162.2

e!Ensembl

Gene	ENSG00000082175
Transcript	ENST00000325455, ENST00000534013, ENST00000528960, ENST00000534780, ENST00000526300, ENST00000263463, ENST00000632634, ENST00000619228, ENST00000617858
Protein	ENSP00000325120, ENSP00000436561, ENSP00000432914, ENSP00000432352, ENSP00000436803, ENSP00000263463, ENSP00000487607, ENSP00000482698, ENSP00000481227

Gene Ontology (GO)

Show/Hide all(13 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007165	Biological process	Signal transduction	TAS	1557371
GO:0007267	Biological process	Cell-cell signaling	TAS	1557371
GO:0010629	Biological process	Negative regulation of gene expression	IEP	21695196
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IDA	17785366
GO:0000978	Molecular function	RNA polymerase II proximal promoter sequence-specific DNA binding	IDA	17785366
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISM	19274049
GO:0000981	Molecular function	DNA-binding transcription factor activity, RNA polymerase II-specific	NAS	19274049
GO:0001228	Molecular function	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	17785366
GO:0003677	Molecular function	DNA binding	TAS	3551956
GO:0005515	Molecular function	Protein binding	IPI	1517211, 12011095, 12612073, 12917342, 17347654, 20876300, 21184768, 22396492, 26153859
GO:0019899	Molecular function	Enzyme binding	IPI	12039952
GO:0042802	Molecular function	Identical protein binding	IPI	17277083, 24909783
GO:0051117	Molecular function	ATPase binding	IDA	12058073

Protein Information

Protein Name

Progesterone receptor, nuclear receptor subfamily 3 group C member 3

Function

The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Depending on the isoform, progesterone receptor functions as transcriptional activator or repressor. .; [Isoform A]: Ligand-dependent transdominant repressor of steroid hormone receptor transcriptional activity including repression of its isoform B, MR and ER. Transrepressional activity may involve recruitment of corepressor NCOR2. .; [Isoform B]: Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation. .; [Isoform 4]: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone

Refseq Proteins

NP_000917.3, , NP_001189403.1, NP_001258090.1, NP_001258091.1

UniProt

P06401

PDB

4OAR, 1A28, 1E3K, 1SQN, 1SR7, 1ZUC, 2C7A, 2OVH, 2OVM, 2W8Y, 3D90, 3G8O, 3HQ5, 3KBA, 3ZR7, 3ZRA, 3ZRB, 4A2J, 4APU, 5CC0

Pfam

Pfam Accession	Pfam ID
PF00104	Hormone_recep
PF02161	Prog_receptor
PF00105	zf-C4