PIBF1: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

PIBF1

Aliases

C13orf24, CEP90, JBTS33, PIBF

Entrez Gene ID

10464

Gene Name

Progesterone immunomodulatory binding factor 1

Chromosomal Location

13q21.33-q22.1

HGNC ID

HGNC:23352

Summary

This gene encodes a protein that is induced by the steroid hormone progesterone and plays a role in the maintenance of pregnancy. The encoded protein regulates multiple facets of the immune system to promote normal pregnancy including cytokine synthesis, natural killer (NK) cell activity, and arachidonic acid metabolism. Low serum levels of this protein have been associated with spontaneous pre-term labor in humans. This protein may promote the proliferation, migration and invasion of glioma. [provided by RefSeq, Mar 2017]

RefSeq DNA

NG_053118.1

RefSeq mRNA

NM_006346.3, NR_146205.2, NR_146206.2, NM_006346.4, NM_001349655.2

e!Ensembl

Gene	ENSG00000083535
Transcript	ENST00000326291, ENST00000617689, ENST00000615625
Protein	ENSP00000317144, ENSP00000478697, ENSP00000483286

Gene Ontology (GO)

Show/Hide all(18 )

GO ID	Ontology	Function	Evidence	Reference
GO:0007080	Biological process	Mitotic metaphase plate congression	IMP	21224392
GO:0031393	Biological process	Negative regulation of prostaglandin biosynthetic process	IDA	3863495
GO:0032695	Biological process	Negative regulation of interleukin-12 production	IDA	14634107
GO:0032733	Biological process	Positive regulation of interleukin-10 production	IDA	14634107
GO:0032815	Biological process	Negative regulation of natural killer cell activation	IDA	12516630
GO:0042531	Biological process	Positive regulation of tyrosine phosphorylation of STAT protein	IDA	16393965
GO:0042532	Biological process	Negative regulation of tyrosine phosphorylation of STAT protein	IDA	16393965
GO:0042976	Biological process	Activation of Janus kinase activity	IDA	16393965
GO:0060271	Biological process	Cilium assembly	IMP	26167768
GO:0071539	Biological process	Protein localization to centrosome	IMP	23110211
GO:0090307	Biological process	Mitotic spindle assembly	IMP	21224392
GO:1905515	Biological process	Non-motile cilium assembly	IMP	23110211
GO:0005615	Cellular component	Extracellular space	IDA	14634107
GO:0005634	Cellular component	Nucleus	IDA	14634107
GO:0005813	Cellular component	Centrosome	IDA	21399614
GO:0034451	Cellular component	Centriolar satellite	IDA	21224392
GO:0005136	Molecular function	Interleukin-4 receptor binding	IDA	16393965
GO:0005515	Molecular function	Protein binding	IPI	17500595, 26297806, 26638075

Protein Information

Protein Name

Progesterone-induced-blocking factor 1, centrosomal protein of 90 kDa

Function

Plays a role in ciliogenesis. .; [Isoform 1]: Pericentriolar protein required to maintain mitotic spindle pole integrity (PubMed:21224392). Required for the centrosomal accumulation of PCM1 and the recruitment of centriolar satellite proteins such as BBS4. Via association with PCM1 may be involved in primary cilia formation (PubMed:23110211). Required for CEP63 centrosomal localization and its interaction with WDR62. Together with CEP63 promotes centriole duplication. Promotes the centrosomal localization of CDK2 (PubMed:26297806). .; [Isoform 4]: The secreted form is a mediator of progesterone that by acting on the phospholipase A2 enzyme interferes with arachidonic acid metabolism, induces a Th2 biased immune response, and by controlling decidual naturakl killer cells (NK) activity exerts an anti-abortive effect (PubMed:14634107, PubMed:3863495, PubMed:12516630). Increases the production of Th2-type cytokines by signaling via the JAK/STAT pathway. Activates STAT6 and inhibits STAT4 phosphorylation. Signaling via a not identified receptor seems to implicate IL4R and a GPI-anchored protein (PubMed:16393965, PubMed:25218441).

Refseq Proteins

NP_006337.2, , NP_001336584.1

UniProt

Q8WXW3