PIK3CG: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

PIK3CG

Aliases

PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K

Entrez Gene ID

5294

Gene Name

Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

Chromosomal Location

7q22.3

HGNC ID

HGNC:8978

Summary

Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids and are involved in the immune response. The protein encoded by this gene is a class I catalytic subunit of PI3K. Like other class I catalytic subunits (p110-alpha p110-beta, and p110-delta), the encoded protein binds a p85 regulatory subunit to form PI3K. This gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2015]

RefSeq DNA

NG_050579.1

RefSeq mRNA

NM_001282426.2, NM_002649.3, NM_001282427.2

e!Ensembl

Gene	ENSG00000105851
Transcript	ENST00000440650, ENST00000496166, ENST00000473541, ENST00000359195
Protein	ENSP00000392258, ENSP00000419260, ENSP00000417623, ENSP00000352121

Gene Ontology (GO)

Show/Hide all(45 )

GO ID	Ontology	Function	Evidence	Reference
GO:0001816	Biological process	Cytokine production	TAS	19075988
GO:0002250	Biological process	Adaptive immune response	TAS	17290298
GO:0002407	Biological process	Dendritic cell chemotaxis	TAS	18278175
GO:0002679	Biological process	Respiratory burst involved in defense response	TAS	19075988
GO:0006954	Biological process	Inflammatory response	TAS	17290298
GO:0007186	Biological process	G protein-coupled receptor signaling pathway	IDA	12507995
GO:0010818	Biological process	T cell chemotaxis	TAS	18278175
GO:0014065	Biological process	Phosphatidylinositol 3-kinase signaling	IBA	21873635
GO:0014065	Biological process	Phosphatidylinositol 3-kinase signaling	IDA	12507995
GO:0014065	Biological process	Phosphatidylinositol 3-kinase signaling	TAS	17290298
GO:0016310	Biological process	Phosphorylation	IDA	25327288
GO:0016477	Biological process	Cell migration	IBA	21873635
GO:0030593	Biological process	Neutrophil chemotaxis	TAS	17290298
GO:0033628	Biological process	Regulation of cell adhesion mediated by integrin	TAS	18278175
GO:0035747	Biological process	Natural killer cell chemotaxis	TAS	18278175
GO:0036092	Biological process	Phosphatidylinositol-3-phosphate biosynthetic process	IBA	21873635
GO:0042098	Biological process	T cell proliferation	TAS	19075988
GO:0042110	Biological process	T cell activation	TAS	17290298
GO:0043303	Biological process	Mast cell degranulation	TAS	17290298
GO:0043406	Biological process	Positive regulation of MAP kinase activity	IDA	12507995
GO:0045087	Biological process	Innate immune response	TAS	17290298
GO:0046854	Biological process	Phosphatidylinositol phosphorylation	IBA	21873635
GO:0048015	Biological process	Phosphatidylinositol-mediated signaling	IBA	21873635
GO:0051897	Biological process	Positive regulation of protein kinase B signaling	IDA	12507995
GO:0055118	Biological process	Negative regulation of cardiac muscle contraction	TAS	19147653
GO:0070527	Biological process	Platelet aggregation	TAS	21035500
GO:0072672	Biological process	Neutrophil extravasation	TAS	18278175
GO:0005737	Cellular component	Cytoplasm	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IDA	12507995
GO:0005886	Cellular component	Plasma membrane	IBA	21873635
GO:0005942	Cellular component	Phosphatidylinositol 3-kinase complex	IBA	21873635
GO:0005944	Cellular component	Phosphatidylinositol 3-kinase complex, class IB	IBA	21873635
GO:0005944	Cellular component	Phosphatidylinositol 3-kinase complex, class IB	IDA	12507995
GO:0016020	Cellular component	Membrane	HDA	19946888
GO:0016020	Cellular component	Membrane	IBA	21873635
GO:0016020	Cellular component	Membrane	IDA	12507995
GO:0004672	Molecular function	Protein kinase activity	TAS	19376709
GO:0005515	Molecular function	Protein binding	IPI	12507995, 21393242, 23824069, 25556234
GO:0016301	Molecular function	Kinase activity	IDA	25327288
GO:0016303	Molecular function	1-phosphatidylinositol-3-kinase activity	IBA	21873635
GO:0035004	Molecular function	Phosphatidylinositol 3-kinase activity	TAS	17290298
GO:0035005	Molecular function	1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA	21873635
GO:0042802	Molecular function	Identical protein binding	IPI	20562859, 23824069
GO:0046875	Molecular function	Ephrin receptor binding	IPI	11416136
GO:0046934	Molecular function	Phosphatidylinositol-4,5-bisphosphate 3-kinase activity	IBA	21873635

Protein Information

Protein Name

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 1-phosphatidylinositol 3-kinase, PI3-kinase subunit gamma, phosphatidylinositol 3 kinase gamma, p110 gamma, phosphatidylinositol 3-kinase catalytic 110-kD gamma, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma, phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, phosphoinositide-3-kinase gamma catalytic subunit, ptdIns-3-kinase subunit gamma, ptdIns-3-kinase subunit p110-gamma, serine/threonine protein kinase PIK3CG

Function

Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Links G-protein coupled receptor activation to PIP3 production. Involved in immune, inflammatory and allergic responses. Modulates leukocyte chemotaxis to inflammatory sites and in response to chemoattractant agents. May control leukocyte polarization and migration by regulating the spatial accumulation of PIP3 and by regulating the organization of F-actin formation and integrin-based adhesion at the leading edge. Controls motility of dendritic cells. Together with PIK3CD is involved in natural killer (NK) cell development and migration towards the sites of inflammation. Participates in T-lymphocyte migration. Regulates T-lymphocyte proliferation and cytokine production. Together with PIK3CD participates in T-lymphocyte development. Required for B-lymphocyte development and signaling. Together with PIK3CD participates in neutrophil respiratory burst. Together with PIK3CD is involved in neutrophil chemotaxis and extravasation. Together with PIK3CB promotes platelet aggregation and thrombosis. Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive function in platelets downstream of P2Y12 through a lipid kinase activity-independent mechanism. May have also a lipid kinase activity-dependent function in platelet aggregation. Involved in endothelial progenitor cell migration. Negative regulator of cardiac contractility. Modulates cardiac contractility by anchoring protein kinase A (PKA) and PDE3B activation, reducing cAMP levels. Regulates cardiac contractility also by promoting beta-adrenergic receptor internalization by binding to GRK2 and by non-muscle tropomyosin phosphorylation. Also has serine/threonine protein kinase activity: both lipid and protein kinase activities are required for beta-adrenergic receptor endocytosis. May also have a scaffolding role in modulating cardiac contractility. Contributes to cardiac hypertrophy under pathological stress. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

Refseq Proteins

NP_001269355.1, NP_002640.2, NP_001269356.1

UniProt

P48736

PDB

1E8Y, 1E8Z, 1HE8, 2A4Z, 2A5U, 2CHW, 2CHX, 2CHZ, 2V4L, 3APC, 3APD, 3APF, 3CSF, 3CST, 3DBS, 3DPD, 3ENE, 3IBE, 3L08, 3L13, 3L16, 3L17, 3L54, 3LJ3, 3MJW, 3ML8, 3ML9, 3NZS, 3NZU, 3OAW, 3P2B, 3PRE, 3PRZ, 3PS6, 3QAQ, 3QAR, 3QJZ, 3QK0, 3R7Q, 3R7R, 3S2A, 3SD5, 3T8M, 3TJP, 3TL5, 3ZVV, 3ZW3, 4ANU, 4ANV, 4ANW, 4ANX,

Pfam

Pfam Accession	Pfam ID
PF00454	PI3_PI4_kinase
PF00792	PI3K_C2
PF00794	PI3K_rbd
PF00613	PI3Ka

PIK3CG

Proteomic analysis of human ovaries from normal and polycystic ovarian syndrome.