PIK3R1: Polycystic Ovarian Syndrome Database

Home

Search
- Quick Search
- Advanced Search

Browse
- Genes
- miRNAs
- SNPs
- Diseases
  - Genes
  - miRNAs
- Pathways
- Ontologies

Tools

Help

PIK3R1

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

PIK3R1

Aliases

AGM7, GRB1, IMD36, p85, p85-ALPHA

Entrez Gene ID

5295

Gene Name

Phosphoinositide-3-kinase regulatory subunit 1

Chromosomal Location

5q13.1

HGNC ID

HGNC:8979

Summary

Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]

RefSeq DNA

NG_012849.2

RefSeq mRNA

NM_181523.3, NM_181523.1, NM_181504.4, NM_181524.2, NM_001242466.2

e!Ensembl

Gene	ENSG00000145675
Transcript	ENST00000521381, ENST00000521657, ENST00000520675, ENST00000523807, ENST00000522084, ENST00000320694, ENST00000521409, ENST00000336483, ENST00000517698, ENST00000519025, ENST00000523872
Protein	ENSP00000428056, ENSP00000429277, ENSP00000428566, ENSP00000430126, ENSP00000429766, ENSP00000323512, ENSP00000431058, ENSP00000338554, ENSP00000430424, ENSP00000429156, ENSP00000430098

Gene Ontology (GO)

Show/Hide all(30 )

GO ID	Ontology	Function	Evidence	Reference
GO:0008286	Biological process	Insulin receptor signaling pathway	IBA	21873635
GO:0014065	Biological process	Phosphatidylinositol 3-kinase signaling	IDA	7782332
GO:0014065	Biological process	Phosphatidylinositol 3-kinase signaling	IMP	21321938
GO:0033120	Biological process	Positive regulation of RNA splicing	IMP	20348923
GO:0034976	Biological process	Response to endoplasmic reticulum stress	IDA	20348923
GO:0042307	Biological process	Positive regulation of protein import into nucleus	IDA	20348923
GO:0043066	Biological process	Negative regulation of apoptotic process	IMP	20348923
GO:0043551	Biological process	Regulation of phosphatidylinositol 3-kinase activity	IBA	21873635
GO:0045944	Biological process	Positive regulation of transcription by RNA polymerase II	IMP	20348923
GO:0046326	Biological process	Positive regulation of glucose import	ISS	8052599
GO:0046854	Biological process	Phosphatidylinositol phosphorylation	IBA	21873635
GO:0048009	Biological process	Insulin-like growth factor receptor signaling pathway	IDA	7782332
GO:0048009	Biological process	Insulin-like growth factor receptor signaling pathway	IPI	7541045
GO:0050821	Biological process	Protein stabilization	IDA	20348923
GO:0060396	Biological process	Growth hormone receptor signaling pathway	IDA	7782332
GO:1900103	Biological process	Positive regulation of endoplasmic reticulum unfolded protein response	IMP	20348923
GO:1903078	Biological process	Positive regulation of protein localization to plasma membrane	ISS	8052599
GO:0005737	Cellular component	Cytoplasm	IDA	20348923
GO:0005942	Cellular component	Phosphatidylinositol 3-kinase complex	IBA	21873635
GO:0016020	Cellular component	Membrane	HDA	19946888
GO:0001784	Molecular function	Phosphotyrosine residue binding	IPI	20624904
GO:0005158	Molecular function	Insulin receptor binding	IPI	7537849
GO:0005159	Molecular function	Insulin-like growth factor receptor binding	IPI	7541045
GO:0005168	Molecular function	Neurotrophin TRKA receptor binding	IPI	15488758
GO:0005515	Molecular function	Protein binding	IPI	1314164, 1330535, 1380456, 1382595, 7536927, 7537096, 7568038, 7584133, 7589433, 7642582, 7657594, 7680095, 7680644, 7692233, 7782332, 7797556, 7807015, 8146197, 8183372, 8276809, 8382612, 8564419, 8603569, 8670861, 9153411, 9160881, 9398332, 9417079, 9593725, 9658397, 9813138, 9890970
GO:0008134	Molecular function	Transcription factor binding	IPI	20348923
GO:0019903	Molecular function	Protein phosphatase binding	IPI	14699157
GO:0043125	Molecular function	ErbB-3 class receptor binding	IDA	10572067
GO:0043559	Molecular function	Insulin binding	IDA	8440175
GO:0046935	Molecular function	1-phosphatidylinositol-3-kinase regulator activity	IBA	21873635

Protein Information

Protein Name

Phosphatidylinositol 3-kinase regulatory subunit alpha, PI3-kinase subunit p85-alpha, PI3K regulatory subunit alpha, phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha, phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha), phosphatidylinositol 3-kinase-associated p-85 alpha, phosphoinositide-3-kinase regulatory subunit alpha, phosphoinositide-3-kinase, regulatory subunit 1 (alpha), ptdIns-3-kinase regulatory subunit alpha

Function

Binds to activated (phosphorylated) protein-Tyr kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Necessary for the insulin-stimulated increase in glucose uptake and glycogen synthesis in insulin-sensitive tissues. Plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role in ITGB2 signaling (PubMed:17626883, PubMed:19805105, PubMed:7518429). Modulates the cellular response to ER stress by promoting nuclear translocation of XBP1 isoform 2 in a ER stress- and/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (PubMed:20348923).

Refseq Proteins

NP_852664.1, NP_852556.2, NP_852665.1, NP_001229395.1

UniProt

P27986

PDB

5AUL, 5GJI, 1A0N, 1AZG, 2IUH, 1H9O, 1PBW, 1PHT, 1PIC, 1PKS, 1PKT, 2IUG, 2IUI, 2RD0, 2V1Y, 3HHM, 3HIZ, 3I5R, 3I5S, 4A55, 4JPS, 4L1B, 4L23, 4L2Y, 4OVU, 4OVV, 4WAF, 4YKN, 4ZOP, 5FI4, 5ITD, 5M6U, 5SW8, 5SWG, 5SWO, 5SWP, 5SWR, 5SWT, 5SX8, 5SX9, 5SXA, 5SXB, 5SXC, 5SXD, 5SXE, 5SXF, 5SXI, 5SXJ, 5SXK, 5UBT, 5UK8,

Pathways
	KEGG	Reactome
	EGFR tyrosine kinase inhibitor resistance Endocrine resistance Platinum drug resistance ErbB signaling pathway Ras signaling pathway Rap1 signaling pathway cAMP signaling pathway Chemokine signaling pathway HIF-1 signaling pathway FoxO signaling pathway Phosphatidylinositol signaling system Sphingolipid signaling pathway Phospholipase D signaling pathway Autophagy - animal mTOR signaling pathway PI3K-Akt signaling pathway AMPK signaling pathway Apoptosis Longevity regulating pathway Longevity regulating pathway - multiple species Cellular senescence Axon guidance VEGF signaling pathway Osteoclast differentiation Focal adhesion Signaling pathways regulating pluripotency of stem cells Platelet activation Toll-like receptor signaling pathway C-type lectin receptor signaling pathway JAK-STAT signaling pathway Natural killer cell mediated cytotoxicity T cell receptor signaling pathway B cell receptor signaling pathway Fc epsilon RI signaling pathway Fc gamma R-mediated phagocytosis TNF signaling pathway Leukocyte transendothelial migration Neurotrophin signaling pathway Cholinergic synapse Inflammatory mediator regulation of TRP channels Regulation of actin cytoskeleton Insulin signaling pathway Progesterone-mediated oocyte maturation Estrogen signaling pathway Prolactin signaling pathway Thyroid hormone signaling pathway Regulation of lipolysis in adipocytes Relaxin signaling pathway Type II diabetes mellitus Insulin resistance Non-alcoholic fatty liver disease (NAFLD) AGE-RAGE signaling pathway in diabetic complications Aldosterone-regulated sodium reabsorption Carbohydrate digestion and absorption Bacterial invasion of epithelial cells Yersinia infection Chagas disease (American trypanosomiasis) Amoebiasis Hepatitis C Hepatitis B Measles Human cytomegalovirus infection Influenza A Human papillomavirus infection Human T-cell leukemia virus 1 infection Kaposi sarcoma-associated herpesvirus infection Herpes simplex virus 1 infection Epstein-Barr virus infection Human immunodeficiency virus 1 infection Pathways in cancer Viral carcinogenesis Proteoglycans in cancer Colorectal cancer Renal cell carcinoma Pancreatic cancer Endometrial cancer Glioma Prostate cancer Melanoma Chronic myeloid leukemia Acute myeloid leukemia Small cell lung cancer Non-small cell lung cancer Breast cancer Hepatocellular carcinoma Gastric cancer Central carbon metabolism in cancer Choline metabolism in cancer PD-L1 expression and PD-1 checkpoint pathway in cancer Fluid shear stress and atherosclerosis	PI3K Cascade IRS-mediated signalling GPVI-mediated activation cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PI3K events in ERBB4 signaling PIP3 activates AKT signaling Interleukin-7 signaling Signaling by SCF-KIT Synthesis of PIPs at the plasma membrane GAB1 signalosome Signaling by cytosolic FGFR1 fusion mutants Downstream signal transduction PI3K events in ERBB2 signaling PI3K/AKT activation Downstream TCR signaling Role of phospholipids in phagocytosis Tie2 Signaling Constitutive Signaling by Aberrant PI3K in Cancer DAP12 signaling Role of LAT2/NTAL/LAB on calcium mobilization Costimulation by the CD28 family CD28 dependent PI3K/Akt signaling G alpha (q) signalling events GP1b-IX-V activation signalling VEGFA-VEGFR2 Pathway Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease Interleukin-4 and Interleukin-13 signaling PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer RET signaling Extra-nuclear estrogen signaling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Interleukin receptor SHC signaling Regulation of signaling by CBL Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants Signaling by PDGFRA extracellular domain mutants Antigen activates B Cell Receptor (BCR) leading to generation of second messengers

Interactions

STRING	MINT	IntAct
ENSP00000282397	P17948	P17948

View interactions

Associated Diseases

Show/Hide all(5 )

Disease group	Disease Name	References
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
	Genetic Diseases	26529633, 25488983, 22351933, 23810379, 23810382, 819054, 27116393, 27076228, 27221134, 23810378, 26497935
Endocrine System Diseases
Endocrine System Diseases	PCOS	17083810
Immune System Diseases
	Immunodeficiency	7705412, 27076228, 25939554, 25741868, 25488983
	Agammaglobulinemia	25741868, 22351933, 25133428
Neoplasms
	Burkitt Lymphoma	23143597
	Prostate cancer	29662167, 29610475
	Glioblastoma	26619011
	Carcinoma	12606953
	Bladder Cancer	26619011
	Brain Neoplasms	26619011
	Ctaneous Melanoma	26619011
	Colorectal Cancer	26619011
	Endometrial Cancer	26619011
	Anaplastic Carcinoma	12606953
Nutritional and Metabolic Diseases
Nutritional and Metabolic Diseases	SHORT syndrome	23810382, 12514365, 23810379, 25741868, 18384141, 8574420, 24088041, 11135494, 26633545, 23810378, 24830046, 6407320, 25326637

References

PMID: 17083810

[Detection and significance of phosphatidylinositol 3-kinase in adipose tissue of polycystic ovary syndrome patients with insulin resistance].

Chu Yong-li, Qiu Hong-yu, Sun Yong-yu, Li Min, Li Hong-fa

Department of Obstetrics and Gynecology, Xiehe Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Zhonghua Fu Chan Ke Za Zhi. 2006 Jul;41(7):455-8.

Statistics

About BIC

Feedback

Links

Contact Us