PLA2G7: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

PLA2G7

Aliases

LDL-PLA2, LP-PLA2, PAFAD, PAFAH

Entrez Gene ID

7941

Gene Name

Phospholipase A2 group VII

Chromosomal Location

6p12.3

HGNC ID

HGNC:9040

Summary

The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]

RefSeq DNA

NG_016204.1

RefSeq mRNA

NM_001168357.1, NM_005084.4

e!Ensembl

Gene	ENSG00000146070
Transcript	ENST00000274793, ENST00000537365
Protein	ENSP00000274793, ENSP00000445666

Gene Ontology (GO)

Show/Hide all(11 )

GO ID	Ontology	Function	Evidence	Reference
GO:0034374	Biological process	Low-density lipoprotein particle remodeling	IDA	8624782
GO:0034440	Biological process	Lipid oxidation	IDA	8624782
GO:0034441	Biological process	Plasma lipoprotein particle oxidation	IDA	8624782
GO:0046469	Biological process	Platelet activating factor metabolic process	IDA	8624782
GO:0050729	Biological process	Positive regulation of inflammatory response	TAS	8624782
GO:0090026	Biological process	Positive regulation of monocyte chemotaxis	IDA	8624782
GO:0034362	Cellular component	Low-density lipoprotein particle	IDA	8624782
GO:0003847	Molecular function	1-alkyl-2-acetylglycerophosphocholine esterase activity	IBA	21873635
GO:0003847	Molecular function	1-alkyl-2-acetylglycerophosphocholine esterase activity	IDA	8624782
GO:0005543	Molecular function	Phospholipid binding	IDA	8624782
GO:0047499	Molecular function	Calcium-independent phospholipase A2 activity	IDA	8624782

Protein Information

Protein Name

Platelet-activating factor acetylhydrolase, 1-alkyl-2-acetylglycerophosphocholine esterase, 2-acetyl-1-alkylglycerophosphocholine esterase, LDL-PLA(2), LDL-associated phospholipase A2, PAF 2-acylhydrolase, PAF acetylhydrolase, gVIIA-PLA2, group-VIIA phospholipase A2, lipoprotein-associated phospholipase A2, phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)

Function

Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids

Refseq Proteins

NP_001161829.1, NP_005075.3

UniProt

Q13093

PDB

3D59, 3D5E, 3F96, 3F97, 3F98, 3F9C, 5I8P, 5I9I, 5JAD, 5JAH, 5JAL, 5JAN, 5JAO, 5JAP, 5JAR, 5JAS, 5JAT, 5JAU, 5LP1, 5LYY, 5LZ2, 5LZ4, 5LZ5, 5LZ7, 5LZ8, 5LZ9, 5YE7, 5YE8, 5YE9, 5YEA

Pfam

Pfam Accession	Pfam ID
PF03403	PAF-AH_p_II