PLAT: Polycystic Ovarian Syndrome Database

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PLAT

Gene Information

Gene Ontology (GO)

Protein Information

Associated Diseases

Pathways

References

Gene Information

Gene Symbol

PLAT

Aliases

T-PA, TPA

Entrez Gene ID

5327

Gene Name

Plasminogen activator, tissue type

Chromosomal Location

8p11.21

HGNC ID

HGNC:9051

Summary

This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]

RefSeq DNA

NG_023264.1

RefSeq mRNA

NM_000930.5, NM_033011.4, NM_001319189.2, NM_000930.3

e!Ensembl

Gene	ENSG00000104368
Transcript	ENST00000429089, ENST00000220809, ENST00000352041, ENST00000519510, ENST00000429710, ENST00000524009, ENST00000521042, ENST00000520523, ENST00000521694
Protein	ENSP00000392045, ENSP00000220809, ENSP00000270188, ENSP00000428886, ENSP00000407861, ENSP00000429401, ENSP00000429542, ENSP00000428797, ENSP00000429801

Gene Ontology (GO)

Show/Hide all(19 )

GO ID	Ontology	Function	Evidence	Reference
GO:0006464	Biological process	Cellular protein modification process	TAS	3087818
GO:0006508	Biological process	Proteolysis	IBA	21873635
GO:0007596	Biological process	Blood coagulation	TAS	3839198
GO:0014909	Biological process	Smooth muscle cell migration	IBA	21873635
GO:0031639	Biological process	Plasminogen activation	IBA	21873635
GO:0031639	Biological process	Plasminogen activation	IDA	12694198, 17849409, 24196407
GO:0045861	Biological process	Negative regulation of proteolysis	IDA	1695900
GO:0048008	Biological process	Platelet-derived growth factor receptor signaling pathway	IBA	21873635
GO:0005615	Cellular component	Extracellular space	IBA	21873635
GO:0005737	Cellular component	Cytoplasm	IDA	1632457
GO:0009986	Cellular component	Cell surface	IDA	1632457
GO:0062023	Cellular component	Collagen-containing extracellular matrix	IDA	1632457
GO:0070062	Cellular component	Extracellular exosome	HDA	20458337
GO:0004252	Molecular function	Serine-type endopeptidase activity	IBA	21873635
GO:0004252	Molecular function	Serine-type endopeptidase activity	IDA	1695900, 8508955
GO:0005102	Molecular function	Signaling receptor binding	IPI	8186264
GO:0005515	Molecular function	Protein binding	IPI	2503541, 10340997, 12694198, 24196407
GO:0005515	Molecular function	Protein binding	TAS	8186264
GO:0051219	Molecular function	Phosphoprotein binding	IPI	8186264

Protein Information

Protein Name

Tissue-type plasminogen activator, alteplase, plasminogen/activator kringle, reteplase, t-plasminogen activator

Function

Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration

Refseq Proteins

NP_000921.1, NP_127509.1, NP_001306118.1

UniProt

P00750

PDB

5BRR, 5ZLZ, 1A5H, 1BDA, 1PK2, 1PML, 1RTF, 1TPG, 1TPK, 1TPM, 1TPN

Pathways
	KEGG	Reactome
	Apelin signaling pathway Complement and coagulation cascades Transcriptional misregulation in cancer Prostate cancer Fluid shear stress and atherosclerosis	Signaling by PDGF Dissolution of Fibrin Clot

Interactions

STRING	MINT	IntAct
ENSP00000356671		P01008

View interactions

Associated Diseases

Show/Hide all(8 )

Disease group	Disease Name	References
Cardiovascular Diseases
	Pulmonary Embolism	8082347, 19415734, 8451030, 9266785, 3105914, 1899825, 3122266, 2123154, 9199818
	Pulmonary thromboembolism	8082347, 2123154, 3122266, 9266785, 1899825, 8451030, 19415734, 9199818, 3105914
	Myocardial Infarction	2521976, 18195371, 10914357, 10645301, 11489769, 1492007, 7775709, 8598594, 19341228, 1899364, 12074692, 7902905, 2494454, 8554022, 15301905, 1430592, 9183334, 10505926, 10171637, 11382373, 3089627, 1900011, 12227717, 2505604, 20122609, 7723950, 2104561, 12589008, 8328192, 15215796, 3
	Hypertensive disease	22352330
	Coronary Thrombosis	1452937, 8172379, 15301905
	Deep Vein Thrombosis	15557913, 19415734, 11144008
	Heart Failure	22352330
	Chylopericardium	9633741
	Myocardial Failure	22352330
	Atherosclerosis	12677255
	Cardiac Tamponade	9633741
	Cholesterol Embolism	7939511
	Pericardial effusion	9633741
	Arterial Occlusive Diseases	15557913
	Embolism and Thrombosis	9684808
Congenital, Hereditary, and Neonatal Diseases and Abnormalities
	Hemorrhages	8961984, 17903947, 11320361, 2104561, 15017018, 7902905, 3168586, 15557913, 15215796, 20536612, 17687131, 20123226, 17612434, 12230423
Digestive System Diseases
	Hepatitis	22507835
	Liver Diseases	22507835
Endocrine System Diseases
Endocrine System Diseases	PCOS	11988309
Immune System Diseases
Immune System Diseases	Dermatitis	17374397
Nervous System Diseases
	Stroke	11239184, 9259745, 19286598, 11108748, 25245553, 9566367, 20705933, 18346647, 7477192, 9836764, 12511774, 14657446, 12384244, 18560214, 9479657, 2124386, 18753472, 11061250, 1598096, 18369171, 9707184, 10572812, 16184341, 17086147, 9400355, 10346413, 18753474, 14986460, 16763187, 150, 12221155, 20536612, 16126134, 17903947, 17612434, 15017018, 11113218, 10171637, 9479658, 14581697, 8427107, 9472885, 15087567, 2514002, 12230423, 1
	Cerebral Ischemia	11940547, 11108748, 17525387, 7477192, 20488584, 20536612, 21037505, 9633741, 20212195, 20123226, 16763187, 17903870, 9566367, 10572812, 9479658, 16126134, 9400355, 12511774, 14986460, 9259745, 16809570, 15017018, 15087567, 12221155, 17086147
	Brain Infarction	20547619, 12297567, 18453163, 17690543, 1579960, 1899364, 9183334, 18544249, 16148626, 15502123, 16190367
	Compression of spinal cord	12227717
	Cerebral Thrombosis	18453163, 12297567, 20547619, 17690543, 7482654, 8427107, 8678742
	Cerebral Thrombus	8678742
	Meningoencephalitis	1430592
	Aphasia	12690208
	Cerebral Artery Infarction	17690543, 20547619, 12297567, 18453163
	Choroidal Artery Infarction	9183334, 18544249, 1579960, 15502123, 1899364, 16148626
	Middle Cerebral Artery Syndrome	20547619, 18453163, 17690543, 12297567, 19057314
	Dejerine-Lichtheim Phenomenon	12690208
	Intracranial Embolism and Thrombosis	7482654, 8427107
	Intracranial Vasospasm	19057314
	Dysphasia	12690208
Psychiatric/Brain disorders
	Schizophrenia	21898905
	Obstructive Sleep Apnea	24497664
Respiratory Tract Diseases
	Respiratory Obstruction	25331496
	Respiratory Failure	25331496

References

Show/Hide all(2)

PubMed ID	Associated gene/s	Associated condition	Genetic Mutation	Diagnostic Criteria	Association with PCOS	Ethnicity	Conclusion
12107238	Testosterone	PCOS		PCOS was defined as androgen excess (total testosterone >3.6 nmol/liter, or a free androgen index9) with ovulatory dysfunction (less than six menstrual cycles per year), once specific disorders such as adult onset congenital adrenal hyperplasia.	Related	Seventeen women with PCOS (defined on the basis of elevated testosterone and oligomenorrhea) and 15 healthy women	The study suggests that elevated t-PA and dysfibrinolysis may be a factor in the increased cardiovascular morbidity seen in PCOS.
9496335		PCOS			Related	11 PCOS, 12 controls	Women with thePCOSmay have an imbalance in theplasminogen activatorsystem that is tilted toward a reduced production of the proteolytic enzyme plasmin.