POLR1B

Gene Information
 
Gene Symbol
POLR1B
 
Aliases
RPA135, RPA2, Rpo1-2
 
Entrez Gene ID
 
Gene Name
RNA polymerase I subunit B
 
Chromosomal Location
2q14.1
 
HGNC ID
 
Summary
Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008]
  e!Ensembl
Gene
Transcript  
Protein

Gene Ontology (GO)

GO ID Ontology Function Evidence Reference
GO:0005736 Cellular component RNA polymerase I complex IBA 21873635
GO:0001054 Molecular function RNA polymerase I activity IBA 21873635
GO:0003899 Molecular function DNA-directed 5'-3' RNA polymerase activity IBA 21873635
GO:0005515 Molecular function Protein binding IPI 16514417, 19214185, 20208542, 26496610
Protein Information
 
Protein Name
DNA-directed RNA polymerase I subunit RPA2, DNA-directed RNA polymerase I 135 kDa polypeptide, DNA-directed RNA polymerase I 135kDa polypeptide, RNA polymerase I subunit 2, polymerase (RNA) I polypeptide B, 128kDa, polymerase (RNA) I subunit B
 
Function
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).
 
UniProt
Pathways
 
KEGG
 
Reactome
 

RNA polymerase

  

B-WICH complex positively regulates rRNA expression
RNA Polymerase I Transcription Initiation
RNA Polymerase I Promoter Escape
RNA Polymerase I Transcription Termination
Interactions
 
STRING MINT IntAct
ENSP00000381382 P15884 P15884
    View interactions
     

Associated Diseases

Disease groupDisease NameReferences
Endocrine System Diseases
PCOS
Nutritional and Metabolic Diseases
Obesity
References
 

Microarray analysis of obese women with polycystic ovary syndrome for key gene screening, key pathway identification and drug prediction.

Wei Lina, Xin Chunlei, Wang Wenjuan, Hao Cuifang
Department of Reproductive Medical, The Affiliated Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, PR China; Department of Reproductive Medical, Jining No. 1 People's Hospital, Jining, Shandong 272011, PR China.| Department of Hematology, Jining No. 1 People's Hospital, Jining, Shandong 272011, PR China.| Department of Reproductive Medical, The Affiliated Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, PR China.| Department of Reproductive Medical, The Affiliated Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, PR China. Electronic address: cuifang-hao@163.com.
Gene. 2018 Jun 30;661:85-94. doi: 10.1016/j.gene.2018.03.079. Epub 2018 Mar 28.
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