POR: Polycystic Ovarian Syndrome Database

Gene Information

Gene Symbol

POR

Aliases

CPR, CYPOR, P450R

Entrez Gene ID

5447

Gene Name

Cytochrome p450 oxidoreductase

Chromosomal Location

7q11.23

HGNC ID

HGNC:9208

Summary

This gene encodes an endoplasmic reticulum membrane oxidoreductase with an FAD-binding domain and a flavodoxin-like domain. The protein binds two cofactors, FAD and FMN, which allow it to donate electrons directly from NADPH to all microsomal P450 enzymes. Mutations in this gene have been associated with various diseases, including apparent combined P450C17 and P450C21 deficiency, amenorrhea and disordered steroidogenesis, congenital adrenal hyperplasia and Antley-Bixler syndrome. [provided by RefSeq, Jul 2008]

RefSeq DNA

NG_008930.1

RefSeq mRNA

NM_000941.2, NM_000941.3, NM_001367562.1

e!Ensembl

Gene	ENSG00000127948
Transcript	ENST00000453773, ENST00000439963, ENST00000461988, ENST00000448410, ENST00000421059, ENST00000394893, ENST00000412521, ENST00000414186, ENST00000432753, ENST00000449920, ENST00000418341, ENST00000412064, ENST00000454934, ENST00000447222, ENST00000426184, ENST00000439297, ENST00000439269
Protein	ENSP00000395813, ENSP00000390540, ENSP00000419970, ENSP00000399409, ENSP00000409881, ENSP00000378355, ENSP00000409238, ENSP00000399327, ENSP00000389409, ENSP00000399556, ENSP00000389719, ENSP00000404731, ENSP00000414263, ENSP00000393527, ENSP00000400964, ENSP00000403494, ENSP00000412490

Gene Ontology (GO)

Show/Hide all(15 )

GO ID	Ontology	Function	Evidence	Reference
GO:0009725	Biological process	Response to hormone	IBA	21873635
GO:0032770	Biological process	Positive regulation of monooxygenase activity	IDA	19448135
GO:0055114	Biological process	Oxidation-reduction process	IDA	19448135
GO:0055114	Biological process	Oxidation-reduction process	TAS	10048323
GO:0090346	Biological process	Cellular organofluorine metabolic process	IDA	19448135
GO:0005829	Cellular component	Cytosol	IBA	21873635
GO:0016020	Cellular component	Membrane	HDA	19946888
GO:0043231	Cellular component	Intracellular membrane-bounded organelle	IDA	9618440
GO:0003958	Molecular function	NADPH-hemoprotein reductase activity	IBA	21873635
GO:0003958	Molecular function	NADPH-hemoprotein reductase activity	IDA	19448135
GO:0003958	Molecular function	NADPH-hemoprotein reductase activity	TAS	2513880, 10048323
GO:0005515	Molecular function	Protein binding	IPI	21081644
GO:0010181	Molecular function	FMN binding	IBA	21873635
GO:0016491	Molecular function	Oxidoreductase activity	IBA	21873635
GO:0050660	Molecular function	Flavin adenine dinucleotide binding	IBA	21873635

Protein Information

Protein Name

NADPH--cytochrome P450 reductase, NADPH--hemoprotein reductase, NADPH-dependent cytochrome P450 reductase, P450 (cytochrome) oxidoreductase

Function

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5

Refseq Proteins

NP_000932.2, NP_000932.3, NP_001354491.1

UniProt

P16435

Pfam

Pfam Accession	Pfam ID
PF00667	FAD_binding_1
PF00258	Flavodoxin_1
PF00175	NAD_binding_1